Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
about
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptorThe unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylationRegulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibitionStructural basis for the recognition of c-Src by its inactivator CskThe tyrosine kinase Csk dimerizes through Its SH3 domainA pharmacological map of the PI3-K family defines a role for p110alpha in insulin signalingLessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemiaErbB receptors: from oncogenes to targeted cancer therapiesAn unbiased cell morphology-based screen for new, biologically active small moleculesThe Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer CellsCrystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanismCrystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemiaTargeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinasesSmall Molecule Recognition of c-Src via the Imatinib-Binding ConformationCrystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound stateEqually Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase ConformationsCrystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation MechanismChemical genetic strategy for targeting protein kinases based on covalent complementarityStructure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistanceStructure-Guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase TechnologyTwo Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated CortactinA pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivoMechanisms of drug resistance in kinases.The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformationRegulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRIThe hunting of the SrcPAK in Alzheimer disease, Huntington disease and X-linked mental retardationCompeting protein:protein interactions are proposed to control the biological switch of the E coli biotin repressorA Src-like inactive conformation in the abl tyrosine kinase domainMutations in the catalytic loop HRD motif alter the activity and function of Drosophila Src64The Structural Basis for Activation and Inhibition of ZAP-70 Kinase DomainCharacterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancerTwo distinct phosphorylation pathways have additive effects on Abl family kinase activationThe Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitmentThe accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.Locking the active conformation of c-Src kinase through the phosphorylation of the activation loop
P2860
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P2860
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
@ast
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
@en
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
@nl
type
label
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
@ast
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
@en
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
@nl
prefLabel
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
@ast
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
@en
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
@nl
P2093
P3181
P1433
P1476
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
@en
P2093
P304
P3181
P356
10.1016/S1097-2765(00)80357-3
P577
1999-05-01T00:00:00Z