Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition
about
The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6Regulated association of protein kinase B/Akt with breast tumor kinaseBrk activates rac1 and promotes cell migration and invasion by phosphorylating paxillinSolution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domainProtein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrateProtein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factorBrk is coamplified with ErbB2 to promote proliferation in breast cancerProtein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor KinaseThe LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancerRole of the Brk SH3 domain in substrate recognitionConstitutive Activity in an Ancestral Form of Abl Tyrosine Kinase.Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma.The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-cateninEvidence for convergent evolution in the signaling properties of a choanoflagellate tyrosine kinaseSignaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulationAn intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.Interaction between Brk kinase and insulin receptor substrate-4.Brk/PTK6 signaling in normal and cancer cell models.Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRKEvolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapyMechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.Protein tyrosine kinase 6 mediates TNFα-induced endothelial barrier dysfunction.Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFRProtein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo.Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.Regulation of Src and Csk nonreceptor tyrosine kinases in the filasterean Ministeria vibransThe nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.
P2860
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P2860
Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Regulation of the nonreceptor ...... rylation and by autoinhibition
@ast
Regulation of the nonreceptor ...... rylation and by autoinhibition
@en
Regulation of the nonreceptor ...... rylation and by autoinhibition
@en-gb
Regulation of the nonreceptor ...... rylation and by autoinhibition
@nl
type
label
Regulation of the nonreceptor ...... rylation and by autoinhibition
@ast
Regulation of the nonreceptor ...... rylation and by autoinhibition
@en
Regulation of the nonreceptor ...... rylation and by autoinhibition
@en-gb
Regulation of the nonreceptor ...... rylation and by autoinhibition
@nl
prefLabel
Regulation of the nonreceptor ...... rylation and by autoinhibition
@ast
Regulation of the nonreceptor ...... rylation and by autoinhibition
@en
Regulation of the nonreceptor ...... rylation and by autoinhibition
@en-gb
Regulation of the nonreceptor ...... rylation and by autoinhibition
@nl
P2860
P921
P356
P1476
Regulation of the nonreceptor ...... rylation and by autoinhibition
@en
P2093
Haoqun Qiu
W Todd Miller
P2860
P304
P356
10.1074/JBC.M203877200
P407
P577
2002-09-13T00:00:00Z