Anatomy of a proficient enzyme: The structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog
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Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMPProduct deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediateUroporphyrinogen decarboxylation as a benchmark for the catalytic proficiency of enzymesCan sequence determine function?Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylaseTesting Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion HoleStructural Characterization of the Molecular Events during a Slow Substrate–Product Transition in Orotidine 5′-Monophosphate DecarboxylaseMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues That Stabilize the Active ConformationThe Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled OligomerizationFrsA functions as a cofactor-independent decarboxylase to control metabolic fluxMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Importance of Residues in the Orotate Binding SiteAtomic Resolution Structure of the Orotidine 5'-Monophosphate Decarboxylase Product Complex Combined with Surface Plasmon Resonance Analysis: IMPLICATIONS FOR THE CATALYTIC MECHANISMEmergent Decarboxylase Activity and Attenuation of α/β-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in TomatoSubstrate Distortion Contributes to the Catalysis of Orotidine 5′-Monophosphate DecarboxylaseThe TIM-barrel fold: a versatile framework for efficient enzymesMolecular dynamics study of active-site interactions with tetracoordinate transients in acetylcholinesterase and its mutantsEffects of macromolecular crowding on protein conformational changesProton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituentMechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.Enzymatic Catalysis of Proton Transfer and Decarboxylation Reactions.Enzymatic catalysis of proton transfer at carbon: activation of triosephosphate isomerase by phosphite dianion.One step construction of PCR mutagenized libraries for genetic analysis by recombination cloning.Inefficient quality control of thermosensitive proteins on the plasma membraneActivation of R235A mutant orotidine 5'-monophosphate decarboxylase by the guanidinium cation: effective molarity of the cationic side chain of Arg-235Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate.Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase.Molecular dynamic study of orotidine-5'-monophosphate decarboxylase in ground state and in intermediate state: a role of the 203-218 loop dynamics.Rescue of K12G triosephosphate isomerase by ammonium cations: the reaction of an enzyme in pieces.Novel reversible indole-3-carboxylate decarboxylase catalyzing nonoxidative decarboxylation.Coupling between catalytic loop motions and enzyme global dynamicsEnzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase.Functional heterologous protein expression by genetically engineered probiotic yeast Saccharomyces boulardii.Functional annotations for the Saccharomyces cerevisiae genome: the knowns and the known unknowns.Comparative polygenic analysis of maximal ethanol accumulation capacity and tolerance to high ethanol levels of cell proliferation in yeastDirect cloning of isogenic murine DNA in yeast and relevance of isogenicity for targeting in embryonic stem cells.OMP decarboxylase: phosphodianion binding energy is used to stabilize a vinyl carbanion intermediate.The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: specificity and enzyme architecture.Accelerated hydrolysis of α-halo and α-cyano pyridinium relative to uracil derivatives: a model for ODCase-catalyzed hydrolysis of 6-cyanoUMPQM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysis
P2860
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P2860
Anatomy of a proficient enzyme: The structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog
description
2000 nî lūn-bûn
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2000年の論文
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Anatomy of a proficient enzyme ...... ential transition state analog
@ast
Anatomy of a proficient enzyme ...... ential transition state analog
@en
Anatomy of a proficient enzyme ...... ential transition state analog
@nl
type
label
Anatomy of a proficient enzyme ...... ential transition state analog
@ast
Anatomy of a proficient enzyme ...... ential transition state analog
@en
Anatomy of a proficient enzyme ...... ential transition state analog
@nl
prefLabel
Anatomy of a proficient enzyme ...... ential transition state analog
@ast
Anatomy of a proficient enzyme ...... ential transition state analog
@en
Anatomy of a proficient enzyme ...... ential transition state analog
@nl
P2093
P2860
P356
P1476
Anatomy of a proficient enzyme ...... ential transition state analog
@en
P2093
A M Hassell
B G Miller
M V Milburn
R Wolfenden
P2860
P304
P356
10.1073/PNAS.030409797
P407
P577
2000-02-29T00:00:00Z