Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme
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Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glandsProdrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)Structures of nitroreductase in three states: effects of inhibitor binding and reductionStructure of RdxA--an oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pyloriStructure and reaction mechanism of a novel enone reductaseAltering the regioselectivity of a nitroreductase in the synthesis of arylhydroxylamines by structure-based engineeringIodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamilyFrancisella tularensis T-cell antigen identification using humanized HLA-DR4 transgenic mice.Temperature dependence of the flexibility of thermophilic and mesophilic flavoenzymes of the nitroreductase foldEfficient use and recycling of the micronutrient iodide in mammalsTargeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.Genetic dissection of drug resistance in trypanosomesNitroreductase: a prodrug-activating enzyme for cancer gene therapy.A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.Crystallization and preliminary X-ray diffraction analysis of ydjA, a minimal nitroreductase from Escherichia coli K12.Reduction of polynitroaromatic compounds: the bacterial nitroreductases.Flavin-containing reductase: new perspective on the detoxification of nitrobenzodiazepine.Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert.Self-immolative bioluminogenic quinone luciferins for NAD(P)H assays and reducing capacity-based cell viability assays.Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.Oxygen-insensitive nitroreductases NfsA and NfsB of Escherichia coli function under anaerobic conditions as lawsone-dependent Azo reductases.Identification of a type I nitroreductase gene in non-virulent Trypanosoma rangeli.Engineering towards nitroreductase functionality in ene-reductase scaffolds.Active site residues critical for flavin binding and 5,6-dimethylbenzimidazole biosynthesis in the flavin destructase enzyme BluB.Role of conformational flexibility for enzymatic activity in NADH oxidase from Thermus thermophilus.Appropriate subcellular localisation of prodrug-activating enzymes has important consequences for suicide gene therapy.Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.Active site dynamics in NADH oxidase from Thermus thermophilus studied by NMR spin relaxation.In silico structure-function analysis of E. cloacae nitroreductase.Conversion of a Dehalogenase into a Nitroreductase by Swapping its Flavin Cofactor with a 5-Deazaflavin Analogue.Bioreductive fluorescent imaging agents: applications to tumour hypoxia.Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal carcinoma.Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase.Activation of the Escherichia coli nfnB gene by MarA through a highly divergent marbox in a class II promoter.A kinetic analysis of three modified novel nitroreductases.
P2860
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P2860
Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Crystal structure of FMN-depen ...... B: a prodrug-activating enzyme
@ast
Crystal structure of FMN-depen ...... B: a prodrug-activating enzyme
@en
Crystal structure of FMN-depen ...... B: a prodrug-activating enzyme
@nl
type
label
Crystal structure of FMN-depen ...... B: a prodrug-activating enzyme
@ast
Crystal structure of FMN-depen ...... B: a prodrug-activating enzyme
@en
Crystal structure of FMN-depen ...... B: a prodrug-activating enzyme
@nl
altLabel
Crystal Structure of FMN-Depen ...... A Prodrug-Activating Enzyme†,‡
@en
prefLabel
Crystal structure of FMN-depen ...... B: a prodrug-activating enzyme
@ast
Crystal structure of FMN-depen ...... B: a prodrug-activating enzyme
@en
Crystal structure of FMN-depen ...... B: a prodrug-activating enzyme
@nl
P2093
P356
P1476
Crystal structure of FMN-depen ...... B: a prodrug-activating enzyme
@en
P2093
G N Parkinson
J V Skelly
P304
P356
10.1021/JM000159M
P407
P577
2000-10-05T00:00:00Z