Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.
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Activation of nitrofurazone by azoreductases: multiple activities in one enzymeStructure and reaction mechanism of a novel enone reductaseAltering the regioselectivity of a nitroreductase in the synthesis of arylhydroxylamines by structure-based engineeringCharacterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori.Flavodoxin:quinone reductase (FqrB): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to NADPH production in Helicobacter pylori and Campylobacter jejuni.Enzymatic activation of nitro-aryl fluorogens in live bacterial cells for enzymatic turnover-activated localization microscopy†Use of nfsB, encoding nitroreductase, as a reporter gene to determine the mutational spectrum of spontaneous mutations in Neisseria gonorrhoeae.Exploring anti-malarial potential of FDA approved drugs: an in silico approach.Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme.Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.Escherichia coli YafP protein modulates DNA damaging property of the nitroaromatic compoundsCharacterization of a pseudomonad 2-nitrobenzoate nitroreductase and its catabolic pathway-associated 2-hydroxylaminobenzoate mutase and a chemoreceptor involved in 2-nitrobenzoate chemotaxis.Crystal structure of the fungal nitroreductase Frm2 from Saccharomyces cerevisiae.Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase.Reduction of polynitroaromatic compounds: the bacterial nitroreductases.E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benzonidazole in Trypanosoma cruziNovel Biodegradable Polymer with Redox-Triggered Backbone Cleavage Through Sequential 1,6-Elimination and 1,5-Cyclization Reactions.The distribution and mechanism of iodotyrosine deiodinase defied expectations.Identification of Enterococcus faecalis enzymes with azoreductases and/or nitroreductase activityEmpirical power laws for the radii of gyration of protein oligomers.Azoreductases in drug metabolism.A rapid response "Turn-On" fluorescent probe for nitroreductase detection and its application in hypoxic tumor cell imaging.Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle.Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole.Hopping into a hot seat: Role of DNA structural features on IS5-mediated gene activation and inactivation under stress."On demand" redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor.Understanding the broad substrate repertoire of nitroreductase based on its kinetic mechanism.NDM-1-producing Klebsiella pneumoniae resistant to colistin in a French community patient without history of foreign travel.Residue Phe42 is critical for the catalytic activity of Escherichia coli major nitroreductase NfsA.Characteristics of major Escherichia coli reductases involved in aerobic nitro and azo reduction.Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase.Aerobic Transformation of 2,4-Dinitrotoluene by Escherichia coli and Its Implications for the Detection of Trace Explosives.A novel off-on fluorescent probe for sensitive imaging of mitochondria-specific nitroreductase activity in living tumor cells.7-((5-Nitrothiophen-2-yl)methoxy)-3H-phenoxazin-3-one as a spectroscopic off-on probe for highly sensitive and selective detection of nitroreductase.A New Tetraphenylethylene-Derived Fluorescent Probe for Nitroreductase Detection and Hypoxic-Tumor-Cell Imaging.Experimental investigation of anion-π interactions--applications and biochemical relevance.Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase.Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy.
P2860
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P2860
Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Structural and mechanistic stu ...... nt redox states of the enzyme.
@en
Structural and mechanistic stu ...... nt redox states of the enzyme.
@nl
type
label
Structural and mechanistic stu ...... nt redox states of the enzyme.
@en
Structural and mechanistic stu ...... nt redox states of the enzyme.
@nl
prefLabel
Structural and mechanistic stu ...... nt redox states of the enzyme.
@en
Structural and mechanistic stu ...... nt redox states of the enzyme.
@nl
P2093
P2860
P50
P356
P1476
Structural and mechanistic stu ...... ent redox states of the enzyme
@en
P2093
Abdelmijd Ossor
Christopher J Wrighton
Paul R Race
Peter F Searle
Richard M Green
P2860
P304
13256-13264
P356
10.1074/JBC.M409652200
P407
P577
2005-01-31T00:00:00Z