Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis
about
Molecular docking as a popular tool in drug design, an in silico travelCrystal structure of D-ribose-5-phosphate isomerase (RpiA) from Escherichia coliStructural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug developmentBiosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinaseStructures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysisStructure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycinStructural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparumCrystal Structure of Brucella abortus Deoxyxylulose-5-phosphate Reductoisomerase-like (DRL) Enzyme Involved in Isoprenoid BiosynthesisAlteration of the Flexible Loop in 1-Deoxy- d -xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by FosmidomycinThe effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cellsIsoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasitesA proposed mechanism for the reductive ring opening of the cyclodiphosphate MEcPP, a crucial transformation in the new DXP/MEP pathway to isoprenoids based on modeling studies and feeding experiments.Lethal mutations in the isoprenoid pathway of Salmonella entericaGenetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids.Specific non-local interactions are not necessary for recovering native protein dynamics.Terpene Specialized Metabolism in Arabidopsis thalianaTargeting the formation of the cell wall core of M. tuberculosis.The non-mevalonate pathway of isoprenoid precursor biosynthesis.The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.Inhibition Studies on Enzymes Involved in Isoprenoid Biosynthesis: Focus on Two Potential Drug Targets: DXR and IDI-2 Enzymes.Mechanistic aspects of carotenoid biosynthesis.Biochemistry of the non-mevalonate isoprenoid pathway.Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis.Crystallization and preliminary X-ray crystallographic study of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Plasmodium falciparum.Conformational dynamics of the flexible catalytic loop in Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate.Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis.Isoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase.Biosynthesis of isoprenoids: studies on the mechanism of 2C-methyl-D-erythritol-4-phosphate synthase.A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.NMR studies of DOXP reductoisomerase and its inhibitor complex.Characterization and functional analysis of the genes encoding 1-deoxy-D-xylulose-5-phosphate reductoisomerase and 1-deoxy-D-xylulose-5-phosphate synthase, the two enzymes in the MEP pathway, from Amomum villosum Lour.20-hydroxyecdysone accumulation and regulation in Ajuga lobata D. Don suspension culture.β-Ecdysterone accumulation and regulation in Ajuga multiflora Bunge suspension culture.
P2860
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P2860
Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis
description
2002 nî lūn-bûn
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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Crystal structure of 1-deoxy-D ...... way of isoprenoid biosynthesis
@ast
Crystal structure of 1-deoxy-D ...... way of isoprenoid biosynthesis
@en
Crystal structure of 1-deoxy-D ...... way of isoprenoid biosynthesis
@nl
type
label
Crystal structure of 1-deoxy-D ...... way of isoprenoid biosynthesis
@ast
Crystal structure of 1-deoxy-D ...... way of isoprenoid biosynthesis
@en
Crystal structure of 1-deoxy-D ...... way of isoprenoid biosynthesis
@nl
prefLabel
Crystal structure of 1-deoxy-D ...... way of isoprenoid biosynthesis
@ast
Crystal structure of 1-deoxy-D ...... way of isoprenoid biosynthesis
@en
Crystal structure of 1-deoxy-D ...... way of isoprenoid biosynthesis
@nl
P2093
P2860
P3181
P356
P1476
Crystal structure of 1-deoxy-D ...... way of isoprenoid biosynthesis
@en
P2093
Ewald Beck
Gerhard Klebe
Hassan Jomaa
Irina Steinbrecher
Jochen Wiesner
Martin Hintz
Silke Sanderbrand
P2860
P304
P3181
P356
10.1074/JBC.M109500200
P407
P577
2001-12-07T00:00:00Z