Reaction path of protein farnesyltransferase at atomic resolution
about
Protein prenyltransferasesStructural basis for the promiscuous biosynthetic prenylation of aromatic natural productsStructure of mammalian protein geranylgeranyltransferase type-IStructures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylationRole of substrate dynamics in protein prenylation reactionsStructural insight into the reaction mechanism and evolution of cytokinin biosynthesisStructure of Protein Geranylgeranyltransferase-I from the Human Pathogen Candida albicans Complexed with a Lipid SubstrateStructural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein FarnesyltransferaseSynthesis, Properties, and Applications of Diazotrifluropropanoyl-Containing Photoactive Analogs of Farnesyl Diphosphate Containing Modified Linkages for Enhanced StabilityStructures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal PathogensStructure of the integral membrane protein CAAX protease Ste24p.Crystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug designThe SNARE Ykt6 is released from yeast vacuoles during an early stage of fusion.Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.Zinc-binding cysteines: diverse functions and structural motifs.Protein kinetics: structures of intermediates and reaction mechanism from time-resolved x-ray data.Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity.Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities.Virtual screening and pharmacophore studies for ftase inhibitors using Indian plant anticancer compounds databaseTherapeutic intervention based on protein prenylation and associated modificationsCombinatorial modulation of protein prenylationCommunication between the zinc and nickel sites in dimeric HypA: metal recognition and pH sensingFarnesyltransferase--new insights into the zinc-coordination sphere paradigm: evidence for a carboxylate-shift mechanism.Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases.Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferaseThe nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics.Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates.Functional characterization of LePGT1, a membrane-bound prenyltransferase involved in the geranylation of p-hydroxybenzoic acid.Protein prenylation: enzymes, therapeutics, and biotechnology applications.Protein prenyltransferases: anchor size, pseudogenes and parasites.Conformational change in substrate binding, catalysis and product release: an open and shut case?Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferaseExploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.Crystal structure of E. coli lipoprotein diacylglyceryl transferase.Dapson in heterocyclic chemistry, part VIII: synthesis, molecular docking and anticancer activity of some novel sulfonylbiscompounds carrying biologically active 1,3-dihydropyridine, chromene and chromenopyridine moieties.Inhibition of farnesyltransferase: a rational approach to treat cancer?Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.Context-dependent substrate recognition by protein farnesyltransferase.Computational enzymatic catalysis--clarifying enzymatic mechanisms with the help of computers.
P2860
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P2860
Reaction path of protein farnesyltransferase at atomic resolution
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Reaction path of protein farnesyltransferase at atomic resolution
@ast
Reaction path of protein farnesyltransferase at atomic resolution
@en
Reaction path of protein farnesyltransferase at atomic resolution
@nl
type
label
Reaction path of protein farnesyltransferase at atomic resolution
@ast
Reaction path of protein farnesyltransferase at atomic resolution
@en
Reaction path of protein farnesyltransferase at atomic resolution
@nl
prefLabel
Reaction path of protein farnesyltransferase at atomic resolution
@ast
Reaction path of protein farnesyltransferase at atomic resolution
@en
Reaction path of protein farnesyltransferase at atomic resolution
@nl
P2093
P2860
P356
P1433
P1476
Reaction path of protein farnesyltransferase at atomic resolution
@en
P2093
Lorena S Beese
Patrick J Casey
Stephen B Long
P2860
P2888
P304
P356
10.1038/NATURE00986
P407
P577
2002-10-10T00:00:00Z
P5875
P6179
1000498088