Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase

Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase

Item
http://www.wikidata.org/entity/Q27653956
Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal PathogensCrystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug designPharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plantsThe discovery of a novel compound with potent antitumor activity: virtual screening, synthesis, biological evaluation and preliminary mechanism study.Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues.Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agentsSynthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications.Exploring protein lipidation with chemical biology.Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.Virtual lead identification of farnesyltransferase inhibitors based on ligand and structure-based pharmacophore techniques.IADE: a system for intelligent automatic design of bioisosteric analogsBinding mode of conformations and structure-based pharmacophore development for farnesyltransferase inhibitorsCurrent and Future Strategies for Improving Drug Discovery Efficiency
P2860

Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase

Item
http://www.wikidata.org/entity/Q27653956
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
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2009年の論文
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2009年論文
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2009年論文
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2009年論文
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2009年論文
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2009年論文
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2009年论文
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10.1016/J.CHEMBIOL.2009.01.014
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