Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens
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Virulence-Associated Enzymes of Cryptococcus neoformansCrystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug designAll about that fat: Lipid modification of proteins in Cryptococcus neoformansIn vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and CandidaRapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues.Antifungal activity of topical microemulsion containing a thiophene derivative.Elucidating drug resistance in human fungal pathogens.Crystal structure of E. coli lipoprotein diacylglyceryl transferase.Synthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications.Relative Contributions of Prenylation and Postprenylation Processing in Cryptococcus neoformans Pathogenesis.Restricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence.Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets.ram1 gene, encoding a subunit of farnesyltransferase, contributes to growth, antifungal susceptibility to amphotericin B of Aspergillus fumigatus.The antifungal pipeline: a reality check.Ras-Mediated Signal Transduction and Virulence in Human Pathogenic Fungi.Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit.Stress Adaptation.The Aspergillus fumigatus farnesyltransferase β-subunit, RamA, mediates growth, virulence, and antifungal susceptibility.Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome.New Horizons in Antifungal Therapy.Lonafarnib synergizes with azoles against Aspergillus spp. and Exophiala spp.Targeting protein localization for anti-infective therapy.Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.
P2860
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P2860
Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Structures of Cryptococcus neo ...... s That Target Fungal Pathogens
@ast
Structures of Cryptococcus neo ...... s That Target Fungal Pathogens
@en
Structures of Cryptococcus neo ...... s That Target Fungal Pathogens
@nl
type
label
Structures of Cryptococcus neo ...... s That Target Fungal Pathogens
@ast
Structures of Cryptococcus neo ...... s That Target Fungal Pathogens
@en
Structures of Cryptococcus neo ...... s That Target Fungal Pathogens
@nl
prefLabel
Structures of Cryptococcus neo ...... s That Target Fungal Pathogens
@ast
Structures of Cryptococcus neo ...... s That Target Fungal Pathogens
@en
Structures of Cryptococcus neo ...... s That Target Fungal Pathogens
@nl
P2093
P2860
P3181
P356
P1476
Structures of Cryptococcus neo ...... s That Target Fungal Pathogens
@en
P2093
Connie B Nichols
Homme W Hellinga
J Andrew Alspaugh
Lorena S Beese
Michael A Hast
Shannon M Kelly
Stephanie M Armstrong
P2860
P304
P3181
P356
10.1074/JBC.M111.250506
P407
P577
2011-10-07T00:00:00Z