Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition - Test2 - elhamkhani - TriplyDB

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

http://www.wikidata.org/entity/Q27641764

about

CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle Raf-1: a novel cardiac troponin T kinase Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITOR Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9 A dual-color fluorescence-based platform to identify selective inhibitors of Akt signaling Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): optimization and selectivity profiling.Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A.Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.Indolocarbazole natural products: occurrence, biosynthesis, and biological activity.Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine.Molecular basis for small molecule inhibition of G protein-coupled receptor kinases Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway.Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death.Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents.Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory.UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors.Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia.Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development.Protein kinase C pharmacology: refining the toolbox.Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons.Binding of BIS like and other ligands with the GSK-3β kinase: a combined docking and MM-PBSA study.Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus.PDK1 regulates chemotaxis in human neutrophils.Mismatch repair system decreases cell survival by stabilizing the tetraploid G1 arrest in response to SN-38.Applying conformational selection theory to improve crossdocking efficiency in 3-phosphoinositide dependent protein kinase-1.Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.Use of photoaffinity labeling and site-directed mutagenesis for identification of the key residue responsible for extraordinarily high affinity binding of UCN-01 in human alpha1-acid glycoprotein.FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis.Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer.New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective

P2860

Q24622357-80024205-B82E-43A1-A521-5E9F2D4F9C25 Q24626540-94B005E2-0AEF-4CB1-B885-6186B056D634 Q27666122-16449DAC-D1BF-4705-8D1B-FC8FAE619078 Q28248842-AF5A1E33-A3D9-430B-B6E3-2845F99D68A3 Q28472406-E39EA48A-35F0-41EB-8C93-530C9429977D Q33493022-0D00783B-E4EB-40F5-B423-14AC29B01962 Q33720256-BFBE4506-FF3F-46E7-8929-53D08EA5DB55 Q34302668-6BB57EBE-8096-424E-B5DF-714A9DC9131D Q34309934-1CCB70C6-F544-4FF0-BCF8-3C234579B369 Q34583547-CB17A009-D2C7-45B6-B417-CFC054E80D25 Q34918248-7361F69B-7D34-48E4-9A43-F14DD60D2346 Q34992803-4FEA7160-D496-40DF-9198-8DDD5AA2AF27 Q34995642-9A2E9F3E-D286-47FB-AD95-E39D8CE13D7B Q35192970-C3DE42B2-4B65-4DA6-90F7-F95EC69F1E49 Q35592015-0307FE04-D707-4F9F-8E69-406D47CF8256 Q35642631-A1AF3309-3B80-486E-B9F5-6A836F27DEF1 Q35849547-304B4EB3-CA6F-4B42-B242-939C860F8202 Q35921522-0660E48B-01E6-4174-9201-352EC30C37AF Q36048547-6D6750BE-3AC4-48AA-993C-67DF7ECAD53F Q36105500-ACA06EB6-34B3-49A0-B187-185E48A27D1D Q36187661-FCAB2CA8-66CD-47F2-B64E-79014031F612 Q36461618-C114BF1A-73EE-4525-8C7B-FF6F6EDD01CF Q36569099-B926D90C-3EA3-44D1-883D-147E1FF2C44A Q37642294-0E40D1D5-2891-43A0-9B5C-D661053BC5C8 Q37650544-709971B1-D82E-43BA-A62C-A7AE4D72E5C6 Q38105600-EFFFA638-8C24-4612-9BB6-4206B1D9FE28 Q39305811-B548C919-52D4-4D00-BBD0-30327C3B7B28 Q39751752-55E986E5-EADB-46BC-90F5-13D366432279 Q40048813-0D1450C9-0A96-4A59-A542-043C81B36FBE Q41846285-14F1C3E5-CB78-4027-9C95-5145F6DD736E Q41856258-676EEAA0-8F71-4A66-95AD-830B1771ACB1 Q41976774-CC525B0E-B809-4392-B178-072B95E8963D Q43490153-48CB2C48-87C1-4CAB-9507-3142EDF2543F Q44655988-F85E713E-0E64-4A04-9DCD-D1D717EC5A4A Q45127785-20613978-5F1A-4FCC-9889-A324084D57E5 Q48156634-8265CB7D-14BD-4DA5-95CE-A2ED50D8BDA8 Q53547402-30828FEC-AB01-4FBF-9720-3BD6067687CB Q58801701-7381939A-079D-40C1-B297-8C52043EE818

P2860

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

http://www.wikidata.org/entity/Q27641764

description

2003 nî lūn-bûn

@nan

2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Structural basis for UCN-01 (7 ...... t protein kinase-1) inhibition

@ast

Structural basis for UCN-01 (7 ...... t protein kinase-1) inhibition

@en

Structural basis for UCN-01 (7 ...... t protein kinase-1) inhibition

@nl

type

label

Structural basis for UCN-01 (7 ...... t protein kinase-1) inhibition

@ast

Structural basis for UCN-01 (7 ...... t protein kinase-1) inhibition

@en

Structural basis for UCN-01 (7 ...... t protein kinase-1) inhibition

@nl

prefLabel

Structural basis for UCN-01 (7 ...... t protein kinase-1) inhibition

@ast

Structural basis for UCN-01 (7 ...... t protein kinase-1) inhibition

@en

Structural basis for UCN-01 (7 ...... t protein kinase-1) inhibition

@nl

P1433

Q27641764-8AF21BB5-5968-4E1E-9C81-0AE096AAE63A

P1476

Q27641764-9EFE053C-162F-4A25-A017-499E4FE6E950

P2093

Q27641764-01ED2BCA-9737-494E-B5A8-EBC20B7DAA02

Q27641764-17CCB5C7-36CD-45F7-BB50-025AA4285BCA

Q27641764-2330B563-D699-4CCC-9FA3-4E71024A1FCF

Q27641764-9A79F774-E0B1-474F-8A61-9E1F760D7CA4

P2860

Q27641764-047213F0-6C70-4AC5-97EF-86D96E9A8387

Q27641764-11D93D10-D078-40E0-A188-708798BED60D

Q27641764-13A940A0-03A4-49F6-918A-61B2B28371BB

Q27641764-1579EF00-9A0D-4D8F-8FB1-0DD2EECBE8CB

Q27641764-17669A04-8B1B-44D2-AABC-39AA3CD5EFF8

Q27641764-1A87AD9B-ECF7-4885-B73A-1153E77BE8BD

Q27641764-1F517A81-8B2C-4E3E-BAD9-D55042922218

Q27641764-2612F86A-8008-42DB-860D-4DA866CC58FE

Q27641764-31C464EA-CA53-43ED-A20A-B9B8E87A915C

Q27641764-366106F4-1826-4596-A8F9-21B9B47F4173

P304

Q27641764-B716ADD9-6F5D-4E49-9592-C93C4D8F6938

P31

Q27641764-182CA5BB-6D76-478D-A242-E1918C62121E

P3181

Q27641764-5E0C765E-7AA2-4E8B-A56E-6829CFD32107

P356

Q27641764-4003E07E-4039-4464-9040-9A69BB8DE791

P407

Q27641764-D7006021-FCE7-42CC-AC91-3F20CA9D48A7

P433

Q27641764-C0A6427A-BFB8-4DDE-97E4-195D17FC1F27

P478

Q27641764-792E6E7C-5D09-40FE-BFAC-CBEB1A083FA0

P50

Q27641764-1C1A2419-B5B9-40FD-BC9A-DFC49CBC16BE

Q27641764-8490F489-D6B6-4829-9A84-097771049C76

P577

Q27641764-9BF1345A-EEFE-4EE4-AB31-84F3FD83EE4F

P698

Q27641764-EDA69472-4FD3-4014-BDEB-BEF808462426

P921

Q27641764-303C4BB3-A8E2-4EBB-B87E-A83EBB70CE30

P932

Q27641764-E8D57CB6-BBCD-48B8-B4D6-5FF1AA11596B

P3181

P356

P1433

Biochemical Journal

P1476

Structural basis for UCN-01 (7 ...... t protein kinase-1) inhibition

@en

P2093

Daan M F Van Aalten

http://www.w3.org/2001/XMLSchema#string

Gursant S Kular

http://www.w3.org/2001/XMLSchema#string

Jennifer Bain

http://www.w3.org/2001/XMLSchema#string

Matthew Elliott

http://www.w3.org/2001/XMLSchema#string

P2860

The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

Phosphorylation and activation of p70s6k by PDK1

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

The PI3K-PDK1 connection: more than just a road to PKB

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

P304

255-62

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4792946

http://www.w3.org/2001/XMLSchema#string

P356

10.1042/BJ20031119

http://www.w3.org/2001/XMLSchema#string

P407

P433

Pt 2

http://www.w3.org/2001/XMLSchema#string

P478

375

http://www.w3.org/2001/XMLSchema#string

P50

P577

2003-10-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

12892559

http://www.w3.org/2001/XMLSchema#string

P921

P932

1223700

http://www.w3.org/2001/XMLSchema#string