about
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeDAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositidesParkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmIdentification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIKPDK1, the master regulator of AGC kinase signal transductionMO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinasesTTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and developmentIdentification of Protor as a novel Rictor-binding component of mTOR complex-2New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesionMechanism of activation of protein kinase B by insulin and IGF-1LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activationThe WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transportersMitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREBPRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocketFAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)PStructural insights into the recognition of substrates and activators by the OSR1 kinase14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localizationRole that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysisWNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrateRole of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1Essential role of PDK1 in regulating cell size and development in miceRegulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilityFunctional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathwayThe selectivity of protein kinase inhibitors: a further updateCancer, oncogenes and signal transductionHigh resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphateStructural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibitionBinding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational changeCrystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptorInteractions of LY333531 and other bisindolyl maleimide inhibitors with PDK1Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Dario R Alessi
@ast
Dario R Alessi
@en
Dario R Alessi
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Dario R Alessi
@nl
Dario R Alessi
@sl
type
label
Dario R Alessi
@ast
Dario R Alessi
@en
Dario R Alessi
@es
Dario R Alessi
@nl
Dario R Alessi
@sl
prefLabel
Dario R Alessi
@ast
Dario R Alessi
@en
Dario R Alessi
@es
Dario R Alessi
@nl
Dario R Alessi
@sl
P106
P21
P31
P496
0000-0002-2140-9185