Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity - Test2 - elhamkhani - TriplyDB

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

http://www.wikidata.org/entity/Q27641774

about

p38 mitogen-activated protein kinase controls NF-kappaB transcriptional activation and tumor necrosis factor alpha production through RelA phosphorylation mediated by mitogen- and stress-activated protein kinase 1 in response to Borrelia burgdorferi Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38 Versatile Loops in Mycocypins Inhibit Three Protease Families Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors Spatial analysis and quantification of the thermodynamic driving forces in protein-ligand binding: binding site variability A small molecule-kinase interaction map for clinical kinase inhibitors A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.A theoretical entropy score as a single value to express inhibitor selectivity.Virtual screening using a conformationally flexible target protein: models for ligand binding to p38α MAPK.Effects of Water Placement on Predictions of Binding Affinities for p38α MAP Kinase Inhibitors.Inclusion of multiple fragment types in the site identification by ligand competitive saturation (SILCS) approach p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening.Quantitative evaluation of positive ϕ angle propensity in flexible regions of proteins from three-bond J couplings Structure and function of Polo-like kinases.TSLP signaling network revealed by SILAC-based phosphoproteomics Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents.Structural basis of p38α regulation by hematopoietic tyrosine phosphatase.p38 pathway kinases as anti-inflammatory drug targets.Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells.An Evaluation of Explicit Receptor Flexibility in Molecular Docking Using Molecular Dynamics and Torsion Angle Molecular Dynamics p38α mitogen-activated protein kinase inhibitors, a patent review (2005-2011).Small-molecule inhibitors binding to protein kinases. Part I: exceptions from the traditional pharmacophore approach of type I inhibition.p38 MAPK inhibitors: a patent review (2012 - 2013).A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors.Design, Synthesis and Biological Evaluation of Novel Substituted N,N'-Diaryl ureas as Potent p38 Inhibitors.The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation Generation and characterization of p38beta (MAPK11) gene-targeted mice.Role for mitogen-activated protein kinase p38 alpha in lung epithelial branching morphogenesis Role of the p38 mitogen-activated protein kinase pathway in the generation of the effects of imatinib mesylate (STI571) in BCR-ABL-expressing cells.Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP.Data driven polypharmacological drug design for lung cancer: analyses for targeting ALK, MET, and EGFR.Pharmacophore modeling using site-identification by ligand competitive saturation (SILCS) with multiple probe molecules.Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis.Kinetic mechanism for p38 MAP kinase alpha. A partial rapid-equilibrium random-order ternary-complex mechanism for the phosphorylation of a protein substrate.A Comprehensive Structural Overview of p38α Mitogen-Activated Protein Kinase in Complex with ATP-Site and Non-ATP-Site Binders.Description and assessment of a model for GSK-3beta database virtual screening.

P2860

Q24678762-B0505A8B-C0B4-45C2-946B-8F31061C03AF Q27654014-268842AE-EE95-4C5D-87B4-FDF33DB54C56 Q27657876-0222D612-A1F3-4B1D-994A-AE88AC37F005 Q27676453-A5137679-548D-4275-82B1-9267EC2DC17E Q27679012-079B86E9-474D-4EBB-95AE-C8DAEED7948C Q27681911-C721D7F8-4493-49F9-8D20-E3818ED3F853 Q28388743-D0F123CA-D7DD-4486-A378-442CB17771ED Q29617451-D4D02EC2-4DC8-4934-B786-E05B6712F708 Q33294239-6A7B3B09-7643-42F5-86CC-81B7C2B763F3 Q33870615-5159B880-F36E-4C4B-A170-CEEA404797F8 Q34243088-C76D9F85-BFB4-4B3F-A9BE-D5DD9E7DF400 Q34530495-5C3FDDE4-A22C-4250-B4B2-81A25F599DC4 Q35045753-7BAAF916-FF38-427C-8AE4-67C03B135F83 Q35762844-9E6EA83E-7D2D-438C-B1B5-5B7459E61ADD Q35790842-1F3B3454-7C00-4395-9665-65FE8E8FC649 Q36004636-81996F6F-F085-4419-9A22-45EA7B65A84F Q36208936-285C3F59-E927-4DCD-8EA1-28ED2DF5B151 Q36459685-36410576-DBA5-4CC8-97A1-835398A0DDF6 Q36852670-F60D3FD3-3615-43A3-8ADD-59A469EF0CD4 Q36919718-59B14635-872C-46C6-8125-954E049BEE0E Q37286265-8D0642E5-38F5-48CC-8354-64A5DBBBD6C6 Q37409322-D75A5072-7519-45C3-A857-E1A8681D7651 Q37955936-E2FC5092-8B81-49D5-9DEF-7C69D10DC633 Q38090663-5E62198A-C585-473E-85CD-129446C1DD31 Q38194600-5CE37482-5552-411F-B432-BDC236E72779 Q38503202-FFD2BF93-F19F-4B43-B0FF-886FE9E66674 Q38963029-F4A87BDE-C6C8-4354-BA6F-704A4D949D00 Q39510138-2936811C-9065-4FFA-B760-9407CB9CA81A Q39732994-FA8268F7-7814-4C0B-BAC5-3713FEFF406B Q39891313-5734A3BB-A276-4AD2-B555-C575FC27EC15 Q40028122-90193554-4BD7-4A80-AC9C-E87206532724 Q40571427-9756B6A5-199A-4297-B202-FDBB8317F542 Q41823565-3E1E6504-28BD-4D6D-B7B6-9C3188973887 Q42697768-2EAC9966-0319-4BE7-9CD8-DA983CA59D2F Q43161207-E6331C41-C8EF-4E3B-B159-7C07748A60BF Q43234873-52C02CBC-D0B4-4AC4-8350-5B5FEEA19C1D Q46698245-376E3E78-75D8-459E-93F7-FE97BBCA304A Q47324721-1DBECBA4-BAF3-41B7-85D4-09EDB7B55238 Q51720330-B091791C-A173-404A-9ED3-B01AF9F6AC3A

P2860

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

http://www.wikidata.org/entity/Q27641774

description

2003 nî lūn-bûn

@nan

2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Structural basis for p38alpha ...... rimidine inhibitor specificity

@ast

Structural basis for p38alpha ...... rimidine inhibitor specificity

@en

Structural basis for p38alpha ...... rimidine inhibitor specificity

@nl

type

label

Structural basis for p38alpha ...... rimidine inhibitor specificity

@ast

Structural basis for p38alpha ...... rimidine inhibitor specificity

@en

Structural basis for p38alpha ...... rimidine inhibitor specificity

@nl

prefLabel

Structural basis for p38alpha ...... rimidine inhibitor specificity

@ast

Structural basis for p38alpha ...... rimidine inhibitor specificity

@en

Structural basis for p38alpha ...... rimidine inhibitor specificity

@nl

P1433

Q27641774-61A6A5FA-2DF3-4CC2-B006-C95D9CEE2888

P1476

Q27641774-862A219B-0A28-4A7F-81E8-5638DAA51FC6

P2093

Q27641774-0627AFC2-D900-440B-AE7F-1F1DCA3E36C2

Q27641774-11FD0061-8BD9-4A9B-A71B-21EB649EBA68

Q27641774-56C38D95-584D-462F-BD43-B51C1DBA2BAB

Q27641774-657BEE43-AFEC-4276-B9F8-D091CCAF52F7

Q27641774-D01564D3-7CE6-488A-A49D-BE736D6D15BE

Q27641774-D681B7BE-8D0E-4551-A472-0DFDF9B40F77

Q27641774-EC5FF066-E2C1-4A18-91DC-9D5492D9CE5C

P2860

Q27641774-0397EC2C-14C5-4888-9F1B-194BD75EFE29

Q27641774-2479EE7D-C1AE-459B-973F-7A2CEA019F4A

Q27641774-260E5847-5EBB-4CE1-8EDE-3CC3465242A8

Q27641774-26101622-AB50-4633-BBBE-DAE56C9E7B7C

Q27641774-26FBA1EE-2E51-4A29-8E52-1EC149091B5E

Q27641774-2A9E8F0B-D8BD-4C22-81FD-36EA2A83AF4B

Q27641774-2BA379C7-2129-4122-8CDA-6DCEDA9C578A

Q27641774-3A0F701D-C219-4F28-B480-759C9C86FC65

Q27641774-3D291E9D-5477-41A1-877B-90D600307AFA

Q27641774-68DBC1FB-A986-4B8A-82D2-1BD07B4D258E

P304

Q27641774-C9A0F6CD-09A7-406B-A0E5-9FBE5542A4F2

P31

Q27641774-B3D5CCF4-4967-4AE3-8034-5966B040834E

P356

Q27641774-8996E5BE-4C9C-41E1-AAA6-E3CF73845918

P433

Q27641774-9416310C-F7A2-41AC-8B5A-585D032A9678

P478

Q27641774-DAB04B95-3E2C-45FB-984D-A054AD8AE338

P50

Q27641774-C8AE9C74-71D0-46A0-BB5E-C0E2DB5580B9

P577

Q27641774-BE5572D9-6F45-4CAD-B745-82BA927FDCC0

P5875

Q27641774-7EB15FB7-B21A-4E3A-ABA1-645291AE5BA5

P698

Q27641774-D9275EED-D195-4C73-AED9-FBDBC05B1AD8

P356

P1433

Nature structural biology

P1476

Structural basis for p38alpha ...... rimidine inhibitor specificity

@en

P2093

Catherine E Fitzgerald

http://www.w3.org/2001/XMLSchema#string

Dennis Zaller

http://www.w3.org/2001/XMLSchema#string

Joseph W Becker

http://www.w3.org/2001/XMLSchema#string

Patricia M Cameron

http://www.w3.org/2001/XMLSchema#string

Sangita B Patel

http://www.w3.org/2001/XMLSchema#string

Stephen J O'Keefe

http://www.w3.org/2001/XMLSchema#string

Vasilis Bill Pikounis

http://www.w3.org/2001/XMLSchema#string

P2860

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Peptide-plane flipping in proteins

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

PROCHECK: a program to check the stereochemical quality of protein structures

Processing of X-ray diffraction data collected in oscillation mode

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase

Crystal structure of p38 mitogen-activated protein kinase

P304

764-9

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NSB949

http://www.w3.org/2001/XMLSchema#string

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

10

http://www.w3.org/2001/XMLSchema#string

P50

Giovanna Scapin

P577

2003-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

10630420

http://www.w3.org/2001/XMLSchema#string

P698

12897767

http://www.w3.org/2001/XMLSchema#string