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A small molecule-kinase interaction map for clinical kinase inhibitors

A small molecule-kinase interaction map for clinical kinase inhibitors

http://www.wikidata.org/entity/Q29617451

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From bytes to bedside: data integration and computational biology for translational cancer research High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation Epithelial membrane protein-1 is a biomarker of gefitinib resistance.The chemical biology of protein phosphorylation On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine Upcoming challenges for multiple sequence alignment methods in the high-throughput era Delineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint Approach Medical treatment for gastro-entero-pancreatic neuroendocrine tumours Vascular Complications of Cancer Chemotherapy An Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of Cholangiocarcinoma Management of regorafenib-related toxicities: a review The dynamic nature of the kinome Diverse roles for MAPK signaling in circadian clocks Bivalent inhibitors of protein kinases Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?Developing irreversible inhibitors of the protein kinase cysteinome EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor Structure and regulation of the human Nek2 centrosomal kinase Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors Optimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity Screen Discovery of Potent and Selective Covalent Inhibitors of JNK Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles A Highly Selective Dual Insulin Receptor (IR)/Insulin-like Growth Factor 1 Receptor (IGF-1R) Inhibitor Derived from an Extracellular Signal-regulated Kinase (ERK) Inhibitor An Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-oxoguanosine Triphosphatase A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity Bioactive cyclometalated phthalimides: design, synthesis and kinase inhibition Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors

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A small molecule-kinase interaction map for clinical kinase inhibitors

http://www.wikidata.org/entity/Q29617451

description

2005 nî lūn-bûn

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2005 թուականի Մարտին հրատարակուած գիտական յօդուած

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2005 թվականի մարտին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

A small molecule-kinase interaction map for clinical kinase inhibitors

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A small molecule-kinase interaction map for clinical kinase inhibitors

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label

A small molecule-kinase interaction map for clinical kinase inhibitors

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A small molecule-kinase interaction map for clinical kinase inhibitors

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prefLabel

A small molecule-kinase interaction map for clinical kinase inhibitors

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A small molecule-kinase interaction map for clinical kinase inhibitors

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Nature Biotechnology

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A small molecule-kinase interaction map for clinical kinase inhibitors

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Atteridge CE

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Azimioara MD

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Benedetti MG

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Biggs WH 3rd

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Floyd M

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Ford JM

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P2860

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

The protein kinase complement of the human genome

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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329-36

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826779

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10.1038/NBT1068

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3

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23

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8020753

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1036157274

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15711537

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