Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors - Test2 - elhamkhani - TriplyDB

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

http://www.wikidata.org/entity/Q27643993

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HIV-Host Interactions: Implications for Vaccine Design Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site High-Throughput Sequencing-Based Immune Repertoire Study during Infectious Disease What Are the Most Powerful Immunogen Design Vaccine Strategies?Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Free Energy Perturbation Calculation of Relative Binding Free Energy between Broadly Neutralizing Antibodies and the gp120 Glycoprotein of HIV-1.Current views on the potential for development of a HIV vaccine.Broadly Neutralizing Antibodies as Treatment: Effects on Virus and Immune System HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies.Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller Probing the Impact of Local Structural Dynamics of Conformational Epitopes on Antibody Recognition.A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection.Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV's Envelope Protein on Viral Replication in Cell Culture Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting.Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1.Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction.Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction.Cross-neutralizing anti-HIV-1 human single chain variable fragments(scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library.Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region Dengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site.Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.Development of Broadly Neutralizing Antibodies and Their Mapping by Monomeric gp120 in Human Immunodeficiency Virus Type 1-Infected Humans and Simian-Human Immunodeficiency Virus SHIVSF162P3N-Infected Macaques.Structural basis for germline antibody recognition of HIV-1 immunogens.Maturational characteristics of HIV-specific antibodies in viremic individuals Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor High-Resolution Longitudinal Study of HIV-1 Env Vaccine-Elicited B Cell Responses to the Virus Primary Receptor Binding Site Reveals Affinity Maturation and Clonal Persistence.A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein.Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency.Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies.Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site.Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding.Progress toward active or passive HIV-1 vaccination.

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Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

http://www.wikidata.org/entity/Q27643993

description

2015 nî lūn-bûn

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2015 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի հունիսին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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Structural Repertoire of HIV-1 ...... the CD4 Supersite in 14 Donors

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Structural Repertoire of HIV-1 ...... the CD4 Supersite in 14 Donors

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Structural Repertoire of HIV-1 ...... the CD4 Supersite in 14 Donors

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Structural Repertoire of HIV-1 ...... the CD4 Supersite in 14 Donors

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J.CELL.2015.05.007

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Structural Repertoire of HIV-1 ...... the CD4 Supersite in 14 Donors

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Aliaksandr Druz

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Anqi Zheng

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Anthony P West

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Baoshan Zhang

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Daniel Lingwood

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Davide Corti

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Dennis R Burton

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Hung-Pin Peng

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Ivelin S Georgiev

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Johannes F Scheid

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P2860

A new clustering of antibody CDR loop conformations

Increasing the potency and breadth of an HIV antibody by using structure-based rational design

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Structural insights on the role of antibodies in HIV-1 vaccine and therapy

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

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1280-92

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scholarly article

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3745454

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10.1016/J.CELL.2015.05.007

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6

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161

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Pamela J. Bjorkman

Michel C. Nussenzweig

Lawrence Shapiro

Stephanie Moquin

Antonio Lanzavecchia

Quentin J Sattentau

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2015-06-04T00:00:00Z

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277011008

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26004070

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