Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases - Test2 - elhamkhani - TriplyDB

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

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Aptamers: A New Technological Platform in Cancer Immunotherapy Structural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan Syndrome Allosteric Autoinhibition Pathway in Transcription Factor ERG: Dynamics Network and Mutant Experimental Evaluations.Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.Current status and perspectives of patient-derived xenograft models in cancer research.Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells.Cancer: Allosteric phosphatase inhibitor puts brake on cancer cells.Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3 SHP2 phosphatase as a novel therapeutic target for melanoma treatment.Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1.Biophysics: for HTS hit validation, chemical lead optimization, and beyond.The impact of structural biology in medicine illustrated with four case studies.Modulation of VEGF receptor 2 signaling by protein phosphatases.Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.Role of SHP2 in hematopoiesis and leukemogenesis.Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets.Targeting Tyrosine Phosphatases: Time to End the Stigma.Strategies for monitoring and combating resistance to combination kinase inhibitors for cancer therapy.Covalent inhibition of protein tyrosine phosphatases.Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice.A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.Sticking It to Cancer with Molecular Glue for SHP2 SHP2 negatively regulates HLA-ABC and PD-L1 expression via STAT1 phosphorylation in prostate cancer cells.Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2.Decline in arylsulfatase B leads to increased invasiveness of melanoma cells.Targeting endogenous proteins for degradation through the affinity-directed protein missile system.SHP2 is required for BCR-ABL1-induced hematologic neoplasia.The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer.EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo.Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3).Maintenance of murine platelet homeostasis by the kinase Csk and the phosphatase CD148.Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor.Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.Exploring the effect of D61G mutation on SHP2 cause gain of function activity by a molecular dynamics study.Therapeutic Targeting of Oncogenic Tyrosine Phosphatases.SHP2 regulates proliferation and tumorigenicity of glioma stem cells.Gain-of-function mutation in PTPN11 in histiocytic sarcomas of Bernese Mountain Dogs.Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors.

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P2860

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

http://www.wikidata.org/entity/Q27644421

description

2016 nî lūn-bûn

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2016 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2016 թվականի հուլիսին հրատարակված գիտական հոդված

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2016年の論文

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2016年学术文章

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2016年学术文章

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2016年学术文章

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Allosteric inhibition of SHP2 ...... n by receptor tyrosine kinases

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Allosteric inhibition of SHP2 ...... n by receptor tyrosine kinases

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Allosteric inhibition of SHP2 ...... n by receptor tyrosine kinases

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Allosteric inhibition of SHP2 ...... n by receptor tyrosine kinases

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Allosteric inhibition of SHP2 ...... n by receptor tyrosine kinases

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Allosteric inhibition of SHP2 ...... n by receptor tyrosine kinases

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Brandon Antonakos

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Brant Firestone

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Cary Fridrich

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Christine Hiu-Tung Chen

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Christopher Quinn

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Denise Grunenfelder

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Dyuti Majumdar

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Edmund Price

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Feng Fei

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Francois Lenoir

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P2860

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy

Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo

Crystal structure of the tyrosine phosphatase SHP-2

Features and development of Coot

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure

Extended kinase profile and properties of the protein kinase inhibitor nilotinib

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.

Voltage-gated sodium channels as therapeutic targets.

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scholarly article

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10.1038/NATURE18621

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7610

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Michael G Acker

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2016-07-07T00:00:00Z

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1047865743

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allosteric inhibitor