Sequential structures provide insights into the fidelity of RNA replication
about
The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerasesRNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory MechanismsCommon and unique features of viral RNA-dependent polymerasesCounteracting Quasispecies Adaptability: Extinction of a Ribavirin-Resistant Virus Mutant by an Alternative Mutagenic TreatmentStructural insights into mechanisms of catalysis and inhibition in Norwalk virus polymeraseCrystal Structure of Coxsackievirus B3 3Dpol Highlights the Functional Importance of Residue 5 in Picornavirus PolymerasesStructure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to RibavirinA Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-EscapeStructural basis for active site closure by the poliovirus RNA-dependent RNA polymeraseStructures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contactsRNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation stateDistinct Conformations of a Putative Translocation Element in Poliovirus PolymeraseThe Crystal Structure of a Cardiovirus RNA-Dependent RNA Polymerase Reveals an Unusual Conformation of the Polymerase Active SiteStructure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymeraseInhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymeraseThe RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus familyEvolution of tertiary structure of viral RNA dependent polymerasesMolecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds.Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells.Molecular dynamics simulations of viral RNA polymerases link conserved and correlated motions of functional elements to fidelityUltra-deep pyrosequencing of partial surface protein genes from infectious Salmon Anaemia virus (ISAV) suggest novel mechanisms involved in transition to virulence.Structural Analysis of Monomeric RNA-Dependent Polymerases: Evolutionary and Therapeutic ImplicationsMotif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide additionIdentification of a novel bovine enterovirus possessing highly divergent amino acid sequences in capsid protein.Residues Arg283, Arg285, and Ile287 in the nucleotide binding pocket of bovine viral diarrhea virus NS5B RNA polymerase affect catalysis and fidelity.Structural features of a picornavirus polymerase involved in the polyadenylation of viral RNA.Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple MutagensDynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?5-fluorouracil in lethal mutagenesis of foot-and-mouth disease virus.Viral polymerases.RNA synthetic mechanisms employed by diverse families of RNA viruses.Three-dimensional structure of foot-and-mouth disease virus and its biological functions.Viruses and viral proteins.Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity.Strong inhibition of betanodavirus replication by ribavirin targeting RNA-dependent RNA polymerase.Foot-and-mouth disease virus low-fidelity polymerase mutants are attenuated.Picornaviral polymerase structure, function, and fidelity modulation.Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis.Bunyaviridae RdRps: structure, motifs, and RNA synthesis machinery.
P2860
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P2860
Sequential structures provide insights into the fidelity of RNA replication
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Sequential structures provide insights into the fidelity of RNA replication
@ast
Sequential structures provide insights into the fidelity of RNA replication
@en
Sequential structures provide insights into the fidelity of RNA replication
@nl
type
label
Sequential structures provide insights into the fidelity of RNA replication
@ast
Sequential structures provide insights into the fidelity of RNA replication
@en
Sequential structures provide insights into the fidelity of RNA replication
@nl
prefLabel
Sequential structures provide insights into the fidelity of RNA replication
@ast
Sequential structures provide insights into the fidelity of RNA replication
@en
Sequential structures provide insights into the fidelity of RNA replication
@nl
P2093
P2860
P50
P3181
P356
P1476
Sequential structures provide insights into the fidelity of RNA replication
@en
P2093
Cristina Escarmís
Cristina Ferrer-Orta
Rosa Pérez-Luque
P2860
P304
P3181
P356
10.1073/PNAS.0700518104
P407
P577
2007-05-29T00:00:00Z