Structure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to Ribavirin
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RNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory MechanismsViral quasispecies evolutionA Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-EscapeStructure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNAThe Crystal Structure of a Cardiovirus RNA-Dependent RNA Polymerase Reveals an Unusual Conformation of the Polymerase Active SiteInhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymeraseMolecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells.Mutagenesis-mediated decrease of pathogenicity as a feature of the mutant spectrum of a viral population.Evaluation of anti-HIV-1 mutagenic nucleoside analogues.Coxsackievirus B3 mutator strains are attenuated in vivo.Residues Arg283, Arg285, and Ile287 in the nucleotide binding pocket of bovine viral diarrhea virus NS5B RNA polymerase affect catalysis and fidelity.Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect modelsArenaviruses and lethal mutagenesis. Prospects for new ribavirin-based interventions.Three-dimensional structure of foot-and-mouth disease virus and its biological functions.Extinction of West Nile virus by Favipiravir through lethal mutagenesis.Picornaviral polymerase structure, function, and fidelity modulation.Ribavirin can be mutagenic for arenaviruses.Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance.Changes in protein domains outside the catalytic site of the bacteriophage Qβ replicase reduce the mutagenic effect of 5-azacytidine.Surface for catalysis by poliovirus RNA-dependent RNA polymerase.β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome.Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases.Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis
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P2860
Structure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to Ribavirin
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structure of Foot-and-Mouth Di ...... duced Sensitivity to Ribavirin
@ast
Structure of Foot-and-Mouth Di ...... duced Sensitivity to Ribavirin
@en
Structure of Foot-and-Mouth Di ...... duced Sensitivity to Ribavirin
@nl
type
label
Structure of Foot-and-Mouth Di ...... duced Sensitivity to Ribavirin
@ast
Structure of Foot-and-Mouth Di ...... duced Sensitivity to Ribavirin
@en
Structure of Foot-and-Mouth Di ...... duced Sensitivity to Ribavirin
@nl
prefLabel
Structure of Foot-and-Mouth Di ...... duced Sensitivity to Ribavirin
@ast
Structure of Foot-and-Mouth Di ...... duced Sensitivity to Ribavirin
@en
Structure of Foot-and-Mouth Di ...... duced Sensitivity to Ribavirin
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Structure of foot-and-mouth di ...... duced sensitivity to ribavirin
@en
P2093
Cristina Escarmís
Cristina Ferrer-Orta
Macarena Sierra
Rosa Pérez-Luque
Rubén Agudo
P2860
P304
P3181
P356
10.1128/JVI.02420-09
P577
2010-04-14T00:00:00Z