Structural basis of histone demethylation by LSD1 revealed by suicide inactivation - Test2 - elhamkhani - TriplyDB

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

http://www.wikidata.org/entity/Q27644954

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The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1 LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition.The role of histone demethylases in cancer therapy Structural Basis for the Inactivation of Thermus thermophilus Proline Dehydrogenase by N- Propargylglycine † , ‡Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1-CoREST Complex Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b Epigenetic polypharmacology: from combination therapy to multitargeted drugs KDM1 class flavin-dependent protein lysine demethylases LSD1 inhibition: a therapeutic strategy in cancer?Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features LSD1 Histone Demethylase Assays and Inhibition Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors Histone modifying enzymes: structures, mechanisms, and specificities.Computational methods for de novo protein design and its applications to the human immunodeficiency virus 1, purine nucleoside phosphorylase, ubiquitin specific protease 7, and histone demethylases.Chemical and biochemical approaches in the study of histone methylation and demethylation A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.Targeting histone lysine demethylases - progress, challenges, and the future Structural insights into histone lysine demethylation.Dynamics of histone lysine methylation: structures of methyl writers and erasers Small-molecular modulators of cancer-associated epigenetic mechanisms.LSD1: biologic roles and therapeutic targeting.Irreversible inactivation of snake venom l-amino acid oxidase by covalent modification during catalysis of l-propargylglycine.Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism.Dynamic protein methylation in chromatin biology.Histone demethylase LSD1 is a folate-binding protein Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation.Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties.MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex.Chemical biology of protein arginine modifications in epigenetic regulation Brain-penetrant LSD1 inhibitors can block memory consolidation.Prognostic role of LSD1 in various cancers: evidence from a meta-analysis Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST.Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones.LSD1 and the chemistry of histone demethylation.Epigenetic regulation of LSD1 during mammary carcinogenesis.Chemical probes for histone-modifying enzymes Chemical biology of lysine demethylases.

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P2860

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

http://www.wikidata.org/entity/Q27644954

description

2007 nî lūn-bûn

@nan

2007 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հունիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

@ast

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

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Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

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type

label

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

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Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

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Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

@nl

prefLabel

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

@ast

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

@en

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

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Nature Structural & Molecular Biology

P1476

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

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P2093

Christian B Gocke

http://www.w3.org/2001/XMLSchema#string

Hongtao Yu

http://www.w3.org/2001/XMLSchema#string

Jeffrey C Culhane

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Lawrence M Szewczuk

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Philip A Cole

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535-9

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scholarly article

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3019496

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10.1038/NSMB1255

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6

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14

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Diana R. Tomchick

Chad A Brautigam

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2007-06-01T00:00:00Z

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6305363

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1024984608

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17529991

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veteran suicide