Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. - Test2 - elhamkhani - TriplyDB

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor.

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor.

http://www.wikidata.org/entity/Q30414643

about

The emerging role of histone lysine demethylases in prostate cancer Design of small molecule epigenetic modulators High-throughput screening to identify inhibitors of lysine demethylases The role of histone demethylases in cancer therapy Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention Epigenetic modulators as therapeutic targets in prostate cancer KDM1 class flavin-dependent protein lysine demethylases Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1 Targeting histone lysine demethylases - progress, challenges, and the future MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.Small-molecular modulators of cancer-associated epigenetic mechanisms.Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats.Small-molecule modulators for epigenetics targets.Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer.Overexpression of SMYD2 contributes to malignant outcome in gastric cancer.Epigenetic regulation of LSD1 during mammary carcinogenesis.Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers.Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.Reversible lysine-specific demethylase 1 antagonist HCI-2509 inhibits growth and decreases c-MYC in castration- and docetaxel-resistant prostate cancer cells.Manipulating the epigenome for the treatment of urological malignancies.LincRNAFEZF1-AS1 represses p21 expression to promote gastric cancer proliferation through LSD1-Mediated H3K4me2 demethylation.Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells.Epigenetic chemical probes.Current trends in epigenetic drug discovery.Histone lysine demethylases as targets for anticancer therapy.Epigenetic molecular recognition: a biomolecular modeling perspective.Targeting the histone orthography of cancer: drugs for writers, erasers and readers.Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date.KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease.LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer.Advances toward LSD1 inhibitors for cancer therapy.Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs.Inhibitors of Protein Methyltransferases and Demethylases.

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P2860

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor.

http://www.wikidata.org/entity/Q30414643

description

2012 nî lūn-bûn

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2012 թվականի հունիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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Impairment of prostate cancer ...... cific demethylase 1 inhibitor.

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Impairment of prostate cancer ...... cific demethylase 1 inhibitor.

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Impairment of prostate cancer ...... cific demethylase 1 inhibitor.

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Impairment of prostate cancer ...... cific demethylase 1 inhibitor.

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Impairment of prostate cancer ...... cific demethylase 1 inhibitor.

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Impairment of prostate cancer ...... cific demethylase 1 inhibitor.

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International Journal of Cancer

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Impairment of prostate cancer ...... cific demethylase 1 inhibitor.

@en

P2093

Andreas Janzer

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Anett Jandausch

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Dominica Willmann

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Eric Metzger

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Ignasi Forne

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Jutta Kirfel

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Reinhard Buettner

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Roland Schüle

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Soyoung Lim

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Stefan Wetzel

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P2860

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25 A

Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

Dali server: conservation mapping in 3D

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

Compound library development guided by protein structure similarity clustering and natural product structure

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2704-2709

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scholarly article

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10.1002/IJC.27555

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11

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131

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Herbert Waldmann

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2012-06-28T00:00:00Z

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221976104

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22447389

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