Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol - Test2 - elhamkhani - TriplyDB

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

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The structure of the NPC1L1 N-terminal domain in a closed conformation Plant sterol metabolism. Δ(7)-Sterol-C5-desaturase (STE1/DWARF7), Δ(5,7)-sterol-Δ(7)-reductase (DWARF5) and Δ(24)-sterol-Δ(24)-reductase (DIMINUTO/DWARF1) show multiple subcellular localizations in Arabidopsis thaliana (Heynh) L Niemann-Pick disease type C Autophagy in lysosomal storage disorders Ebola virus entry requires the host-programmed recognition of an intracellular receptor The formation and function of ER-endosome membrane contact sites Genetic and laboratory diagnostic approach in Niemann Pick disease type C Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk Genetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type C The lysosome: from waste bag to potential therapeutic target Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling There Is No Simple Model of the Plasma Membrane Organization Binding domain-driven intracellular trafficking of sterols for synthesis of steroid hormones, bile acids and oxysterols Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model Characterization of the Niemann-Pick C pathway in alveolar type II cells and lamellar bodies of the lung Loss of Niemann-Pick C1 or C2 protein results in similar biochemical changes suggesting that these proteins function in a common lysosomal pathway Alteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stress Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding The Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments.EhNPC1 and EhNPC2 Proteins Participate in Trafficking of Exogenous Cholesterol in Entamoeba histolytica Trophozoites: Relevance for Phagocytosis.ECOD: an evolutionary classification of protein domains.Visual evoked potentials of Niemann-Pick type C1 mice reveal an impairment of the visual pathway that is rescued by 2-hydroxypropyl-ß-cyclodextrin Proteins that bind and move lipids: MsbA and NPC1.A cholesterol recognition amino acid consensus domain in GP64 fusion protein facilitates anchoring of baculovirus to mammalian cells.Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease.Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation.The National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes.Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration.Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells.Multi-system disorders of glycosphingolipid and ganglioside metabolism Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin STARTing to understand MLN64 function in cholesterol transport.NPC1L1 and cholesterol transport Cholesterol, the central lipid of mammalian cells Reduced VLDL clearance in Apoe(-/-)Npc1(-/-) mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels.Therapeutic potential of cyclodextrins in the treatment of Niemann-Pick type C disease.Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity.A marked paucity of granule cells in the developing cerebellum of the Npc1(-/-) mouse is corrected by a single injection of hydroxypropyl-β-cyclodextrin Oxidative stress in Niemann-Pick disease, type C

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Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

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Structure of N-Terminal Domain ...... ng and Transfer of Cholesterol

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Michael S Brown

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P2860

Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization

Topological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-acti

Identification of HE1 as the second gene of Niemann-Pick C disease

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

Regulation of sterol transport between membranes and NPC2

Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease

NPC1/NPC2 function as a tag team duo to mobilize cholesterol

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structural Basis of Sterol Binding by NPC2, a Lysosomal Protein Deficient in Niemann-Pick Type C2 Disease

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