Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol
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The structure of the NPC1L1 N-terminal domain in a closed conformationPlant sterol metabolism. Δ(7)-Sterol-C5-desaturase (STE1/DWARF7), Δ(5,7)-sterol-Δ(7)-reductase (DWARF5) and Δ(24)-sterol-Δ(24)-reductase (DIMINUTO/DWARF1) show multiple subcellular localizations in Arabidopsis thaliana (Heynh) LNiemann-Pick disease type CAutophagy in lysosomal storage disordersEbola virus entry requires the host-programmed recognition of an intracellular receptorThe formation and function of ER-endosome membrane contact sitesGenetic and laboratory diagnostic approach in Niemann Pick disease type CMechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease riskGenetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type CThe lysosome: from waste bag to potential therapeutic targetStructure and function of the Smoothened extracellular domain in vertebrate Hedgehog signalingThere Is No Simple Model of the Plasma Membrane OrganizationBinding domain-driven intracellular trafficking of sterols for synthesis of steroid hormones, bile acids and oxysterolsChronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse modelCharacterization of the Niemann-Pick C pathway in alveolar type II cells and lamellar bodies of the lungLoss of Niemann-Pick C1 or C2 protein results in similar biochemical changes suggesting that these proteins function in a common lysosomal pathwayAlteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stressActivation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cellsNiemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 bindingThe Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments.EhNPC1 and EhNPC2 Proteins Participate in Trafficking of Exogenous Cholesterol in Entamoeba histolytica Trophozoites: Relevance for Phagocytosis.ECOD: an evolutionary classification of protein domains.Visual evoked potentials of Niemann-Pick type C1 mice reveal an impairment of the visual pathway that is rescued by 2-hydroxypropyl-ß-cyclodextrinProteins that bind and move lipids: MsbA and NPC1.A cholesterol recognition amino acid consensus domain in GP64 fusion protein facilitates anchoring of baculovirus to mammalian cells.Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease.Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation.The National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes.Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration.Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells.Multi-system disorders of glycosphingolipid and ganglioside metabolismNiemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrinSTARTing to understand MLN64 function in cholesterol transport.NPC1L1 and cholesterol transportCholesterol, the central lipid of mammalian cellsReduced VLDL clearance in Apoe(-/-)Npc1(-/-) mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels.Therapeutic potential of cyclodextrins in the treatment of Niemann-Pick type C disease.Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity.A marked paucity of granule cells in the developing cerebellum of the Npc1(-/-) mouse is corrected by a single injection of hydroxypropyl-β-cyclodextrinOxidative stress in Niemann-Pick disease, type C
P2860
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P2860
Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structure of N-Terminal Domain ...... ng and Transfer of Cholesterol
@ast
Structure of N-Terminal Domain ...... ng and Transfer of Cholesterol
@en
Structure of N-Terminal Domain ...... ng and Transfer of Cholesterol
@nl
type
label
Structure of N-Terminal Domain ...... ng and Transfer of Cholesterol
@ast
Structure of N-Terminal Domain ...... ng and Transfer of Cholesterol
@en
Structure of N-Terminal Domain ...... ng and Transfer of Cholesterol
@nl
prefLabel
Structure of N-Terminal Domain ...... ng and Transfer of Cholesterol
@ast
Structure of N-Terminal Domain ...... ng and Transfer of Cholesterol
@en
Structure of N-Terminal Domain ...... ng and Transfer of Cholesterol
@nl
P2093
P2860
P50
P3181
P1433
P1476
Structure of N-Terminal Domain ...... ng and Transfer of Cholesterol
@en
P2093
Hyock Joo Kwon
Lina Abi-Mosleh
Michael L Wang
Michael S Brown
P2860
P304
P3181
P356
10.1016/J.CELL.2009.03.049
P407
P577
2009-06-26T00:00:00Z