Alteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stress
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Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C miceGenomic expression analyses reveal lysosomal, innate immunity proteins, as disease correlates in murine models of a lysosomal storage disorderPre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick Type C1-deficient murine brainGpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C DiseaseExtensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis.Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells.Altered transition metal homeostasis in Niemann-Pick disease, type C1.Oxidative stress: a pathogenic mechanism for Niemann-Pick type C disease.Quantitative Proteomics of Human Fibroblasts with I1061T Mutation in Niemann-Pick C1 (NPC1) Protein Provides Insights into the Disease Pathogenesis.Microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease, type C1.Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism.Efficacy of N-acetylcysteine in phenotypic suppression of mouse models of Niemann-Pick disease, type C1.Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway.Human and mouse neuroinflammation markers in Niemann-Pick disease, type C1.Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease.New murine Niemann-Pick type C models bearing a pseudoexon-generating mutation recapitulate the main neurobehavioural and molecular features of the disease.Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.Plasma signature of neurological disease in the monogenetic disorder Niemann-Pick Type C.In Silico Identification of Proteins Associated with Drug-induced Liver Injury Based on the Prediction of Drug-target Interactions.Altered Met Receptor Phosphorylation and LRP1 Mediated Uptake in Cells Lacking Carbohydrate-Dependent Lysosomal Targeting.Vitamin E dietary supplementation improves neurological symptoms and decreases c-Abl/p73 activation in Niemann-Pick C miceTranscriptomic signature of high dietary organic selenium supplementation in sheep: A nutrigenomic insight using a custom microarray platform and gene set enrichment analysis.Increased copper levels in in vitro and in vivo models of Niemann-Pick C disease.Hepatic metabolic response to restricted copper intake in a Niemann-Pick C murine model.Adaptive responses of mitochondria to mild copper deprivation involve changes in morphology, OXPHOS remodeling and bioenergetics.Chitosan-triclosan particles modulate inflammatory signaling in gingival fibroblasts.Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease.Mitochondrial G8292A and C8794T mutations in patients with Niemann-Pick disease type C.
P2860
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P2860
Alteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stress
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
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2011 թվականին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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Alteration of gene expression ...... ue damage and oxidative stress
@ast
Alteration of gene expression ...... ue damage and oxidative stress
@en
Alteration of gene expression ...... ue damage and oxidative stress
@nl
type
label
Alteration of gene expression ...... ue damage and oxidative stress
@ast
Alteration of gene expression ...... ue damage and oxidative stress
@en
Alteration of gene expression ...... ue damage and oxidative stress
@nl
prefLabel
Alteration of gene expression ...... ue damage and oxidative stress
@ast
Alteration of gene expression ...... ue damage and oxidative stress
@en
Alteration of gene expression ...... ue damage and oxidative stress
@nl
P2093
P2860
P1433
P1476
Alteration of gene expression ...... ue damage and oxidative stress
@en
P2093
Felipe Olivares
Fermín A Robledo
Mary C Vázquez
Mauricio González
Silvana Zanlungo
Talía del Pozo
P2860
P304
P356
10.1371/JOURNAL.PONE.0028777
P407
P577
2011-12-22T00:00:00Z