The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules
about
The interaction of CK2α and CK2β, the subunits of protein kinase CK2, requires CK2β in a preformed conformation and is enthalpically drivenStructure of human protein kinase CK2α2 with a potent indazole-derivative inhibitorStructural basis of CX-4945 binding to human protein kinase CK2A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinaseEnzymatic activity with an incomplete catalytic spine: insights from a comparative structural analysis of human CK2α and its paralogous isoform CK2α'Crystal structure of human CK2α at 1.06 Å resolutionStructure of the Toxoplasma gondii ROP18 Kinase Domain Reveals a Second Ligand Binding Pocket Required for Acute VirulenceLow-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing biasCell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potentialIdentification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases.Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2.ITC-derived binding affinity may be biased due to titrant (nano)-aggregation. Binding of halogenated benzotriazoles to the catalytic domain of human protein kinase CK2.Cystic fibrosis as a bowel cancer syndrome and the potential role of CK2.Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model.In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface.Protein kinase CK2 inhibitors: a patent review.Harnessing allostery: a novel approach to drug discovery.A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.Casein kinases as potential therapeutic targets.Dynamic profile analysis to characterize dynamics-driven allosteric sites in enzymes.Conformational flexibility of human casein kinase catalytic subunit explored by metadynamics.Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins.CaMKII Regulates Synaptic NMDA Receptor Activity of Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension.Mass Spectrometry Reveals Protein Kinase CK2 High-Order Oligomerization via the Circular and Linear Assembly.Allosteric sites can be identified based on the residue-residue interaction energy difference.Insights into the Impact of Linker Flexibility and Fragment Ionization on the Design of CK2 Allosteric Inhibitors: Comparative Molecular Dynamics Simulation Studies.A novel allosteric site in casein kinase 2α discovered using combining bioinformatics and biochemistry methods.Evidence for aggregation of protein kinase CK2 in the cell: a novel strategy for studying CK2 holoenzyme interaction by BRET(2).Underlying mechanisms of cyclic peptide inhibitors interrupting the interaction of CK2α/CK2β: comparative molecular dynamics simulation studies.
P2860
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P2860
The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The CK2 alpha/CK2 beta interfa ...... ing pocket for small molecules
@ast
The CK2 alpha/CK2 beta interfa ...... ing pocket for small molecules
@en
The CK2 alpha/CK2 beta interfa ...... ing pocket for small molecules
@nl
type
label
The CK2 alpha/CK2 beta interfa ...... ing pocket for small molecules
@ast
The CK2 alpha/CK2 beta interfa ...... ing pocket for small molecules
@en
The CK2 alpha/CK2 beta interfa ...... ing pocket for small molecules
@nl
prefLabel
The CK2 alpha/CK2 beta interfa ...... ing pocket for small molecules
@ast
The CK2 alpha/CK2 beta interfa ...... ing pocket for small molecules
@en
The CK2 alpha/CK2 beta interfa ...... ing pocket for small molecules
@nl
P3181
P1476
The CK2 alpha/CK2 beta interfa ...... ing pocket for small molecules
@en
P2093
Elena Brunstein
Jennifer Raaf
P3181
P356
10.1016/J.CHEMBIOL.2007.12.012
P577
2008-02-01T00:00:00Z