Stabilization of a -hairpin in monomeric Alzheimer's amyloid- peptide inhibits amyloid formation
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β-hairpin-mediated formation of structurally distinct multimers of neurotoxic prion peptidesHuman serum albumin inhibits Abeta fibrillization through a "monomer-competitor" mechanismAlzheimer's disease--a panorama glimpseStructures of Aβ-Related Peptide−Monoclonal Antibody Complexes ,Minimalist design of water-soluble cross-beta architecture.Structural basis for high-affinity HER2 receptor binding by an engineered proteinCharacteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet MimicsX-ray Crystallographic Structures of Trimers and Higher-Order Oligomeric Assemblies of a Peptide Derived from Aβ 17–36Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumabA Fibril-Like Assembly of Oligomers of a Peptide Derived from β-AmyloidSequestration of a β-hairpin for control of α-synuclein aggregationNanobodies and recombinant binders in cell biologyNMR structure of the water soluble Aβ17-34 peptideInfluence of preformed Asp23-Lys28 salt bridge on the conformational fluctuations of monomers and dimers of Abeta peptides with implications for rates of fibril formationSequestration of the Abeta peptide prevents toxicity and promotes degradation in vivoInteraction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptideA foldamer-dendrimer conjugate neutralizes synaptotoxic β-amyloid oligomersCommon features at the start of the neurodegeneration cascadeAmyloid-β protofibrils: size, morphology and synaptotoxicity of an engineered mimicFibrils of Truncated Pyroglutamyl-Modified Aβ Peptide Exhibit a Similar Structure as Wildtype Mature Aβ FibrilsAntiparallel triple-strand architecture for prefibrillar Aβ42 oligomersAggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFMToxic fibrillar oligomers of amyloid-β have cross-β structure.Mapping the interactions between the Alzheimer's Aβ-peptide and human serum albumin beyond domain resolution.Nano-assembly of amyloid β peptide: role of the hairpin fold.Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aβ amyloid aggregates.Alternative binding proteins: affibody binding proteins developed from a small three-helix bundle scaffold.Recombinant amyloid beta-peptide production by coexpression with an affibody ligand.Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases.Structural Changes of Amyloid Beta in Hippocampus of Rats Exposed to Ozone: A Raman Spectroscopy Study.Transient formation of intermediate conformational states of amyloid-β peptide revealed by heteronuclear magnetic resonance spectroscopy.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineeringFibril elongation by Aβ(17-42): kinetic network analysis of hybrid-resolution molecular dynamics simulationsMechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane.Structural insights for engineering binding proteins based on non-antibody scaffoldsDominance of misfolded intermediates in the dynamics of α-helix foldingStaphylococcal display for combinatorial protein engineering of a head-to-tail affibody dimer binding the Alzheimer amyloid-β peptide.Multiplex epitope mapping using bacterial surface display reveals both linear and conformational epitopes.Structural basis of IL-23 antagonism by an Alphabody protein scaffold
P2860
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P2860
Stabilization of a -hairpin in monomeric Alzheimer's amyloid- peptide inhibits amyloid formation
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Stabilization of a -hairpin i ...... ide inhibits amyloid formation
@ast
Stabilization of a -hairpin i ...... ide inhibits amyloid formation
@en
Stabilization of a -hairpin i ...... ide inhibits amyloid formation
@nl
type
label
Stabilization of a -hairpin i ...... ide inhibits amyloid formation
@ast
Stabilization of a -hairpin i ...... ide inhibits amyloid formation
@en
Stabilization of a -hairpin i ...... ide inhibits amyloid formation
@nl
prefLabel
Stabilization of a -hairpin i ...... ide inhibits amyloid formation
@ast
Stabilization of a -hairpin i ...... ide inhibits amyloid formation
@en
Stabilization of a -hairpin i ...... ide inhibits amyloid formation
@nl
P2860
P50
P3181
P356
P1476
Stabilization of a -hairpin i ...... ide inhibits amyloid formation
@en
P2093
Andreas Jonsson
P2860
P304
P3181
P356
10.1073/PNAS.0711731105
P407
P577
2008-04-01T00:00:00Z