Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) †
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Fine-tuning multiprotein complexes using small moleculesRecognition of Smac-mimetic compounds by the BIR domain of cIAP1Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-MimeticThe structure of XIAP BIR2: understanding the selectivity of the BIR domainsEctopic expression of new alternative splice variant of Smac/DIABLO increases mammospheres formationThe Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancerUltra-High-Throughput Structure-Based Virtual Screening for Small-Molecule Inhibitors of Protein-Protein Interactions.Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134.Transient pockets on XIAP-BIR2: toward the characterization of putative binding sites of small-molecule XIAP inhibitors.Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.Cyclopeptide Smac mimetics as antagonists of IAP proteins.Druggable protein interaction sites are more predisposed to surface pocket formation than the rest of the protein surfaceMechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells.Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.Design of small-molecule peptidic and nonpeptidic Smac mimetics.A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice.Importance of ligand reorganization free energy in protein-ligand binding-affinity prediction.NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.Design, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics.X-linked inhibitor of apoptosis protein - a critical death resistance regulator and therapeutic target for personalized cancer therapy.Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist.Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer.X-Linked Inhibitor of Apoptosis Protein (XIAP) is a Client of Heat Shock Protein 70 (Hsp70) and a Biomarker of its Inhibition.
P2860
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P2860
Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) †
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structure-Based Design, Synthe ...... of Apoptosis Protein (XIAP) †
@ast
Structure-Based Design, Synthe ...... of Apoptosis Protein (XIAP) †
@en
Structure-Based Design, Synthe ...... of Apoptosis Protein (XIAP) †
@nl
type
label
Structure-Based Design, Synthe ...... of Apoptosis Protein (XIAP) †
@ast
Structure-Based Design, Synthe ...... of Apoptosis Protein (XIAP) †
@en
Structure-Based Design, Synthe ...... of Apoptosis Protein (XIAP) †
@nl
prefLabel
Structure-Based Design, Synthe ...... of Apoptosis Protein (XIAP) †
@ast
Structure-Based Design, Synthe ...... of Apoptosis Protein (XIAP) †
@en
Structure-Based Design, Synthe ...... of Apoptosis Protein (XIAP) †
@nl
P2093
P2860
P921
P356
P1476
Structure-based design, synthe ...... or of apoptosis protein (XIAP)
@en
P2093
Chao-Yie Yang
Dongguang Qin
Haiying Sun
Jeanne A Stuckey
Jennifer L Meagher
Jianfeng Lu
Naoyuki G Saito
Zaneta Nikolovska-Coleska
P2860
P304
P356
10.1021/JM8006849
P407
P50
P577
2008-11-01T00:00:00Z