Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain - Test2 - elhamkhani - TriplyDB

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

http://www.wikidata.org/entity/Q27629143

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SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane XIAP: cell death regulation meets copper homeostasis A novel role for XIAP in copper homeostasis through regulation of MURR1 VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation Identification of a novel protein kinase Cδ-Smac complex that dissociates during paclitaxel-induced cell death ARTS and Siah collaborate in a pathway for XIAP degradation Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs.Upstream regulatory role for XIAP in receptor-mediated apoptosis Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites Opposite regulation of XIAP and Smac/DIABLO in the rat endometrium in response to 17beta-estradiol at estrus SMAC is expressed de novo in a subset of cervical cancer tumors Novel strategies to target the ubiquitin proteasome system in multiple myeloma Small-molecule SMAC mimetics as new cancer therapeutics Survivin - biology and potential as a therapeutic target in oncology Targeting the apoptosis pathway in hematologic malignancies Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization Crystal Structure of the BIR1 Domain of XIAP in Two Crystal Forms Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein † ‡Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) †Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)The structure of XIAP BIR2: understanding the selectivity of the BIR domains Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity Ectopic expression of new alternative splice variant of Smac/DIABLO increases mammospheres formation Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9 Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15 Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells

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P2860

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

http://www.wikidata.org/entity/Q27629143

description

2000 nî lūn-bûn

@nan

2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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type

label

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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prefLabel

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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C Sun

http://www.w3.org/2001/XMLSchema#string

E T Olejniczak

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J C Wu

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J Herrmann

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R P Meadows

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S F Betz

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S W Fesik

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T Oost

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Z Liu

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1004-8

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3376132

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10.1038/35050006

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