The Structure of the Cataract-Causing P23T Mutant of Human γD-Crystallin Exhibits Distinctive Local Conformational and Dynamic Changes † , ‡
about
Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallinsDetermination of Multicomponent Protein Structures in Solution Using Global Orientation and Shape RestraintsStructure and function of the regulatory HRDC domain from human Bloom syndrome proteinThe Human W42R D-Crystallin Mutant Structure Provides a Link between Congenital and Age-related CataractsStructure and Dynamics of the Fish Eye Lens Protein, γM7-CrystallinCrystal structure of the cataract-causing P23T γD-crystallin mutantSolution NMR Structures of Pyrenophora tritici-repentis ToxB and Its Inactive Homolog Reveal Potential Determinants of Toxin ActivitySwitch region for pathogenic structural change in conformational disease and its predictionExome sequencing identifies novel and recurrent mutations in GJA8 and CRYGD associated with inherited cataract.Conformational stability as a design target to control protein aggregation.Cataract-associated P23T γD-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH.A single destabilizing mutation (F9S) promotes concerted unfolding of an entire globular domain in gammaS-crystallin.Phase behavior of mixtures of human lens proteins Gamma D and Beta B1.Solvent accessibility of betaB2-crystallin and local structural changes due to deamidation at the dimer interface.Defective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins.A recurrent mutation in CRYGD is associated with autosomal dominant congenital coralliform cataract in two unrelated Chinese familiesStructural integrity of the Greek key motif in βγ-crystallins is vital for central eye lens transparencyCharacterization of a transient unfolding intermediate in a core mutant of γS-crystallin.Wild-type human γD-crystallin promotes aggregation of its oxidation-mimicking, misfolding-prone W42Q mutant.Structural and biochemical characterization of the childhood cataract-associated R76S mutant of human γD-crystallin.Novel mutations in CRYGD are associated with congenital cataracts in Chinese families.Single-molecule Force Spectroscopy Predicts a Misfolded, Domain-swapped Conformation in human γD-Crystallin ProteinEvolution of crystallins for a role in the vertebrate eye lens.Protein misfolding and aggregation in cataract disease and prospects for prevention.Hydrophobic core mutations associated with cataract development in mice destabilize human gammaD-crystallin.Increased hydrophobicity and decreased backbone flexibility explain the lower solubility of a cataract-linked mutant of γD-crystallin.Structural and aggregation behavior of the human γD-crystallin mutant E107A, associated with congenital nuclear cataractAggregation of Trp > Glu point mutants of human gamma-D crystallin provides a model for hereditary or UV-induced cataract.Increase in surface hydrophobicity of the cataract-associated P23T mutant of human gammaD-crystallin is responsible for its dramatically lower, retrograde solubility.A missense mutation in CRYGD linked with autosomal dominant congenital cataract of aculeiform type.
P2860
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P2860
The Structure of the Cataract-Causing P23T Mutant of Human γD-Crystallin Exhibits Distinctive Local Conformational and Dynamic Changes † , ‡
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The Structure of the Cataract- ...... onal and Dynamic Changes † , ‡
@ast
The Structure of the Cataract- ...... onal and Dynamic Changes † , ‡
@en
The Structure of the Cataract- ...... onal and Dynamic Changes † , ‡
@nl
type
label
The Structure of the Cataract- ...... onal and Dynamic Changes † , ‡
@ast
The Structure of the Cataract- ...... onal and Dynamic Changes † , ‡
@en
The Structure of the Cataract- ...... onal and Dynamic Changes † , ‡
@nl
prefLabel
The Structure of the Cataract- ...... onal and Dynamic Changes † , ‡
@ast
The Structure of the Cataract- ...... onal and Dynamic Changes † , ‡
@en
The Structure of the Cataract- ...... onal and Dynamic Changes † , ‡
@nl
P2093
P2860
P356
P1433
P1476
The Structure of the Cataract- ...... onal and Dynamic Changes † , ‡
@en
P2093
In-Ja L Byeon
Jonathan King
Yongting Wang
P2860
P304
P356
10.1021/BI802292Q
P407
P577
2009-03-31T00:00:00Z