An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene - Test2 - elhamkhani - TriplyDB

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

http://www.wikidata.org/entity/Q27654825

about

TOPSAN: a collaborative annotation environment for structural genomics RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosis Folate binding site of flavin-dependent thymidylate synthase Mechanistic and structural basis for inhibition of thymidylate synthase ThyX Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design Deprotonations in the Reaction of Flavin-Dependent Thymidylate Synthase The place of RNA in the origin and early evolution of the genetic machinery Discovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue.Substrate activation in flavin-dependent thymidylate synthase.Three-dimensional structural view of the central metabolic network of Thermotoga maritima.Crystallization and preliminary crystallographic studies of a flavin-dependent thymidylate synthase from Helicobacter pylori.Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster.Pathogenomic inference of virulence-associated genes in Leptospira interrogans.Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis Mechanisms and inhibition of uracil methylating enzymes.An unprecedented mechanism of nucleotide methylation in organisms containing thyX.Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1.Invited review: MnmE, a GTPase that drives a complex tRNA modification reaction.Insights into folate/FAD-dependent tRNA methyltransferase mechanism: role of two highly conserved cysteines in catalysis.DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position.Collaborative drug discovery for More Medicines for Tuberculosis (MM4TB).Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase.Flavin-dependent thymidylate synthase: a novel pathway towards thymine.Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones Detection of intermediates in the oxidative half-reaction of the FAD-dependent thymidylate synthase from Thermotoga maritima: carbon transfer without covalent pyrimidine activation.Synthesis and application of isotopically labeled flavin nucleotides Oxidase activity of a flavin-dependent thymidylate synthase.Substrate interaction dynamics and oxygen control in the active site of thymidylate synthase ThyX.Ligands in crystal structures that aid in functional characterization.Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier.Chemo-enzymatic synthesis of the exocyclic olefin isomer of thymidine monophosphate.Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.Unique Features and Anti-microbial Targeting of Folate- and Flavin-Dependent Methyltransferases Required for Accurate Maintenance of Genetic Information.New Insight into the Octamer of TYMS Stabilized by Intermolecular Cys43-Disulfide.

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P2860

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

http://www.wikidata.org/entity/Q27654825

description

2009 nî lūn-bûn

@nan

2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի ապրիլին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

@ast

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

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An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

@nl

type

label

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

@ast

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

@en

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

@nl

prefLabel

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

@ast

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

@en

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

@nl

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An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

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Amnon Kohen

http://www.w3.org/2001/XMLSchema#string

Eric M Koehn

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Irimpan I Mathews

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John A Conrad

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Scott A Lesley

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Todd Fleischmann

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P2860

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline.

Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein

Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate

On the active site of Old Yellow Enzyme. Role of histidine 191 and asparagine 194

An alternative flavin-dependent mechanism for thymidylate synthesis

The catalytic mechanism and structure of thymidylate synthase

Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution

Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.

Synthesis of stable-isotope enriched 5-methylpyrimidines and their use as probes of base reactivity in DNA.

Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases.

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10.1038/NATURE07973

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1010541793

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