about
Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reductionInteraction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactisAn unusual mechanism of thymidylate biosynthesis in organisms containing the thyX geneA single intersubunit salt bridge affects oligomerization and catalytic activity in a bacterial quinone reductaseFlavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangementQuinone reductase acts as a redox switch of the 20S yeast proteasome.Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification.Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 levelComparing protein-ligand interactions in solution and single crystals by Raman spectroscopy.On the interpretation of quantitative structure-function activity relationship data for lactate oxidase.An analysis of the solution structure and signaling mechanism of LovK, a sensor histidine kinase integrating light and redox signalsBiochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor.Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases.Single-molecule kinetics reveals signatures of half-sites reactivity in dihydroorotate dehydrogenase A catalysisSubstrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenaseKinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase.Oxygen reactivity in flavoenzymes: context matters.On the reaction mechanism of L-lactate oxidase: quantitative structure-activity analysis of the reaction with para-substituted L-mandelates.The dimeric dihydroorotate dehydrogenase A from Lactococcus lactis dissociates reversibly into inactive monomers.Control of catalysis in flavin-dependent monooxygenases.A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme.Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase.Oxidation mode of pyranose 2-oxidase is controlled by pH.Catalytic function of the conserved hydroxyl group in the protein tyrosine phosphatase signature motif.Detection of intermediates in the oxidative half-reaction of the FAD-dependent thymidylate synthase from Thermotoga maritima: carbon transfer without covalent pyrimidine activation.Disruption of the proton relay network in the class 2 dihydroorotate dehydrogenase from Escherichia coli.Conformational dynamics of the isoalloxazine in substrate-free p-hydroxybenzoate hydroxylase: single-molecule studies.Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli.The cation-π interaction between Lys53 and the flavin of fructosamine oxidase (FAOX-II) is critical for activity.Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies.Protein dynamics control proton transfers to the substrate on the His72Asn mutant of p-hydroxybenzoate hydroxylase.Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis.Specific inhibition of a family 1A dihydroorotate dehydrogenase by benzoate pyrimidine analogues.Role of protein flexibility in the catalytic cycle of p-hydroxybenzoate hydroxylase elucidated by the Pro293Ser mutant.The lipoamide dehydrogenase from Mycobacterium tuberculosis permits the direct observation of flavin intermediates in catalysis.Altered balance of half-reactions in p-hydroxybenzoate hydroxylase caused by substituting the 2'-carbon of FAD with fluorine.Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single-molecule kinetics.Direct observation of the participation of flavin in product formation by thyX-encoded thymidylate synthase.Kinetics of proton-linked flavin conformational changes in p-hydroxybenzoate hydroxylase.Analysis of the kinetic isotope effects on initial rates in transient kinetics.
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Bruce Palfey
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Bruce Palfey
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Bruce Palfey
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Bruce Palfey
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Bruce Palfey
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type
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Bruce Palfey
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Bruce Palfey
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Bruce Palfey
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Bruce Palfey
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Bruce Palfey
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Bruce Palfey
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Bruce Palfey
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Bruce Palfey
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Bruce Palfey
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Bruce Palfey
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P106
P1153
6603718025
P21
P31
P496
0000-0001-5098-259X