Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase.
about
Flavin-Dependent Thymidylate Synthase as a New Antibiotic TargetFolate binding site of flavin-dependent thymidylate synthaseMechanistic and structural basis for inhibition of thymidylate synthase ThyXFlavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor DesignDeprotonations in the Reaction of Flavin-Dependent Thymidylate SynthaseQM/MM calculations suggest a novel intermediate following the proton abstraction catalyzed by thymidylate synthaseSubstrate activation in flavin-dependent thymidylate synthase.An unprecedented mechanism of nucleotide methylation in organisms containing thyX.DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position.Role of long-range protein dynamics in different thymidylate synthase catalyzed reactions.Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinonesDetection of intermediates in the oxidative half-reaction of the FAD-dependent thymidylate synthase from Thermotoga maritima: carbon transfer without covalent pyrimidine activation.Synthesis and application of isotopically labeled flavin nucleotidesSubstrate interaction dynamics and oxygen control in the active site of thymidylate synthase ThyX.Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier.Chemo-enzymatic synthesis of the exocyclic olefin isomer of thymidine monophosphate.Unique Features and Anti-microbial Targeting of Folate- and Flavin-Dependent Methyltransferases Required for Accurate Maintenance of Genetic Information.
P2860
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P2860
Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Trapping of an intermediate in ...... ependent thymidylate synthase.
@en
Trapping of an intermediate in ...... ependent thymidylate synthase.
@nl
type
label
Trapping of an intermediate in ...... ependent thymidylate synthase.
@en
Trapping of an intermediate in ...... ependent thymidylate synthase.
@nl
prefLabel
Trapping of an intermediate in ...... ependent thymidylate synthase.
@en
Trapping of an intermediate in ...... ependent thymidylate synthase.
@nl
P2093
P2860
P356
P1476
Trapping of an intermediate in ...... dependent thymidylate synthase
@en
P2093
Amnon Kohen
Eric M Koehn
John A Conrad
Scott A Lesley
Tatiana V Mishanina
P2860
P304
P356
10.1021/JA2120822
P407
P50
P577
2012-02-24T00:00:00Z