The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.
about
Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamicsStructural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activationStructural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteinsSwing-out of the β3 hybrid domain is required for αIIbβ3 priming and normal cytoskeletal reorganization, but not adhesion to immobilized fibrinogenThe talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clusteringStructure of a double ubiquitin-like domain in the talin head: a role in integrin activationCentral Region of Talin Has a Unique Fold That Binds Vinculin and ActinThe Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM DomainNMR analysis of the IIb 3 cytoplasmic interaction suggests a mechanism for integrin regulationStructural basis of the junctional anchorage of the cerebral cavernous malformations complexTyrosine Phosphorylation as a Conformational Switch: A CASE STUDY OF INTEGRIN 3 CYTOPLASMIC TAILMembrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin ActivationMechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin ActivationRIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and TurnoverBasic amino-acid side chains regulate transmembrane integrin signallingCharacterization of 14-3-3-ζ Interactions with Integrin TailsStructural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1)Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activationA novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesionBiology and structure of leukocyte β 2 integrins and their role in inflammationPIP kinases define PI4,5P₂signaling specificity by association with effectorsInitial activation of STIM1, the regulator of store-operated calcium entryMechanical dynamics in live cells and fluorescence-based force/tension sensorsOsteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition.Matrix adhesion polarizes heart progenitor induction in the invertebrate chordate Ciona intestinalisDrosophila integrin adhesion complexes are essential for hemocyte migration in vivo.New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering.The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis.Integrin αII b tail distal of GFFKR participates in inside-out αII b β3 activation.Structural basis of transmembrane domain interactions in integrin signaling.Talins and kindlins: partners in integrin-mediated adhesion.The final steps of integrin activation: the end gameStructural diversity in integrin/talin interactions.Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3.Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.Clustered diffusion of integrins.
P2860
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P2860
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The structure of an integrin/t ...... inside-out signal transduction
@nl
The structure of an integrin/t ...... nside-out signal transduction.
@ast
The structure of an integrin/t ...... nside-out signal transduction.
@en
type
label
The structure of an integrin/t ...... inside-out signal transduction
@nl
The structure of an integrin/t ...... nside-out signal transduction.
@ast
The structure of an integrin/t ...... nside-out signal transduction.
@en
prefLabel
The structure of an integrin/t ...... inside-out signal transduction
@nl
The structure of an integrin/t ...... nside-out signal transduction.
@ast
The structure of an integrin/t ...... nside-out signal transduction.
@en
P2093
P2860
P3181
P356
P1433
P1476
The structure of an integrin/t ...... inside-out signal transduction
@en
P2093
Chungho Kim
David R Critchley
Edward D Lowe
Iain D Campbell
Ioannis Vakonakis
Kate L Wegener
Mark H Ginsberg
Nicholas J Anthis
P2860
P304
P3181
P356
10.1038/EMBOJ.2009.287
P407
P577
2009-10-01T00:00:00Z