Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein - Test2 - elhamkhani - TriplyDB

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

http://www.wikidata.org/entity/Q27659586

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Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn region A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain Conservation of a crystallographic interface suggests a role for β-sheet augmentation in influenza virus NS1 multifunctionality The Influenza A Virus Protein NS1 Displays Structural Polymorphism New small-molecule drug design strategies for fighting resistant influenza A Oncolytic effects of a novel influenza A virus expressing interleukin-15 from the NS reading frame Characterization of a novel mutation in NS1 protein of influenza A virus induced by a chemical substance for the attenuation of pathogenicity Avian influenza viruses inhibit the major cellular signalling integrator c-Abl.Heterologous SH3-p85beta inhibits influenza A virus replication.Survival analysis of infected mice reveals pathogenic variations in the genome of avian H1N1 viruses Structures of influenza A proteins and insights into antiviral drug targets.Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translation.Innate immune response to influenza A virus in differentiated human alveolar type II cells The influenza virus NS1 protein as a therapeutic target.Effects of the C-terminal truncation in NS1 protein of the 2009 pandemic H1N1 influenza virus on host gene expression.An overview of the highly pathogenic H5N1 influenza virus.A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection.(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus.Conserved and host-specific features of influenza virion architecture.Short self-interacting N-terminal region of rubella virus capsid protein is essential for cooperative actions of capsid and nonstructural p150 proteins.Appearance of L90I and N205S Mutations in Effector Domain of NS1 Gene of pdm (09) H1N1 Virus from India during 2009-2013.The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection A comprehensive map of the influenza A virus replication cycle Generation of replication-proficient influenza virus NS1 point mutants with interferon-hyperinducer phenotype.Strain-specific contribution of NS1-activated phosphoinositide 3-kinase signaling to influenza A virus replication and virulence.Mutations Designed by Ensemble Defect to Misfold Conserved RNA Structures of Influenza A Segments 7 and 8 Affect Splicing and Attenuate Viral Replication in Cell Culture Identification of combinatorial host-specific signatures with a potential to affect host adaptation in influenza A H1N1 and H3N2 subtypes.Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition.Evaluation of phosphatidylinositol-4-kinase IIIα as a hepatitis C virus drug target Synergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus.SUMOylation affects the interferon blocking activity of the influenza A nonstructural protein NS1 without affecting its stability or cellular localization.Polyproline and triple helix motifs in host-pathogen recognition.Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site During Circulation in Humans.An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response.Novel roles of focal adhesion kinase in cytoplasmic entry and replication of influenza A viruses The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm.PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target.Contribution of double-stranded RNA and CPSF30 binding domains of influenza virus NS1 to the inhibition of type I interferon production and activation of human dendritic cells.Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins.

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Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

http://www.wikidata.org/entity/Q27659586

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Structural insights into phosp ...... influenza A virus NS1 protein

@ast

Structural insights into phosp ...... influenza A virus NS1 protein

@en

Structural insights into phosp ...... influenza A virus NS1 protein

@nl

type

label

Structural insights into phosp ...... influenza A virus NS1 protein

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Structural insights into phosp ...... influenza A virus NS1 protein

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Structural insights into phosp ...... influenza A virus NS1 protein

@nl

prefLabel

Structural insights into phosp ...... influenza A virus NS1 protein

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Structural insights into phosp ...... influenza A virus NS1 protein

@en

Structural insights into phosp ...... influenza A virus NS1 protein

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Proceedings of the National Academy of Sciences of the United States of America

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Structural insights into phosp ...... influenza A virus NS1 protein

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Bernard L Precious

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David Jackson

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Marian J Killip

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Philip S Kerry

http://www.w3.org/2001/XMLSchema#string

Rupert J Russell

http://www.w3.org/2001/XMLSchema#string

P2860

Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling

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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

AKT/PKB signaling: navigating downstream

Improved methods for building protein models in electron density maps and the location of errors in these models

The NPro Product of Bovine Viral Diarrhea Virus Inhibits DNA Binding by Interferon Regulatory Factor 3 and Targets It for Proteasomal Degradation

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

Structure of an avian influenza A virus NS1 protein effector domain

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41408690

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20133840

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