Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
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Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25STRAD pseudokinases regulate axogenesis and LKB1 stabilityRap2A links intestinal cell polarity to brush border formationMO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinasesA secretory kinase complex regulates extracellular protein phosphorylationMolecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical DevelopmentMechanisms of innate immunity in C. elegans epidermis6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signallingTen things you should know about protein kinases: IUPHAR Review 14ILK: a pseudokinase in the center stage of cell-matrix adhesion and signalingMitotic exit and separation of mother and daughter cellsThe polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 proteinA Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma VirulenceStructural insights into the activation of MST3 by MO25Structure of zebrafish MO25Structure and Identification of a Pterin Dehydratase-like Protein as a Ribulose-bisphosphate Carboxylase/Oxygenase (RuBisCO) Assembly Factor in the α-CarboxysomeDomain-Swapping Switch Point in Ste20 Protein Kinase SPAKStructure and inhibition analysis of the mouse SAD-B C-terminal fragmentSmall molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signallingSignalling scaffolds and local organization of cellular behaviourSTE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cellsActivation of AMPK by bitter melon triterpenoids involves CaMKKβIn Vitro Anti-Echinococcal and Metabolic Effects of Metformin Involve Activation of AMP-Activated Protein Kinase in Larval Stages of Echinococcus granulosusProtein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neuronsInvestigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activityThe Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent mannerTGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansionProtein kinases: evolution of dynamic regulatory proteinsStructural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.Pseudokinases: update on their functions and evaluation as new drug targets.MultiBac complexomics.Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorderEnhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cellsA novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and miceMetformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities.The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases.The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.
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P2860
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@ast
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@en
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@en-gb
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@nl
type
label
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@ast
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@en
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@en-gb
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@nl
altLabel
Structure of the LKB1-STRAD-MO ...... Mechanism of Kinase Activation
@en
prefLabel
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@ast
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@en
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@en-gb
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@nl
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P1476
Structure of the LKB1-STRAD-MO ...... mechanism of kinase activation
@en
P2093
Daan M F van Aalten
P2860
P304
P3181
P356
10.1126/SCIENCE.1178377
P407
P577
2009-12-18T00:00:00Z