Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase
about
Structural Insight into the Tetramerization of an Iterative Ketoreductase SiaM through Aromatic Residues in the InterfacesStructural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide KetoreductaseThe Missing Linker: A Dimerization Motif Located within Polyketide Synthase ModulesStructural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent StereochemistryStructural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-AlkeneDivergence of multimodular polyketide synthases revealed by a didomain structureStructural and functional studies of atrans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreductionDomain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferaseCharacterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreusInsights into the biosynthesis of 12-membered resorcylic acid lactones from heterologous production in Saccharomyces cerevisiae.On the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotation.Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchangeModeling holo-ACP:DH and holo-ACP:KR complexes of modular polyketide synthases: a docking and molecular dynamics study.Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis.Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains.Molecular dynamics studies of modular polyketide synthase ketoreductase stereospecificity.Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues.Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases.Structural analysis of protein-protein interactions in type I polyketide synthasesCoupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange.Polyketide stereocontrol: a study in chemical biology.The structures of type I polyketide synthases.Dissecting complex polyketide biosynthesis.Stereocontrol within polyketide assembly lines.The structural biology of biosynthetic megaenzymes.Towards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects.Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis.Structure and mechanism of assembly line polyketide synthases.Structural rearrangements of a polyketide synthase module during its catalytic cycle.Structure of a modular polyketide synthase.A fungal ketoreductase domain that displays substrate-dependent stereospecificity.Substrate structure-activity relationships guide rational engineering of modular polyketide synthase ketoreductases.An enzymatic domain for the formation of cyclic ethers in complex polyketides.Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay.Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis.Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products.Engineered polyketides: Synergy between protein and host level engineering.Insights into the stereospecificity of ketoreduction in a modular polyketide synthase.Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.Structural and Functional Trends in Dehydrating Bimodules from trans-Acyltransferase Polyketide Synthases.
P2860
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P2860
Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structural and functional anal ...... in modular polyketide synthase
@ast
Structural and functional anal ...... in modular polyketide synthase
@en
Structural and functional anal ...... in modular polyketide synthase
@nl
type
label
Structural and functional anal ...... in modular polyketide synthase
@ast
Structural and functional anal ...... in modular polyketide synthase
@en
Structural and functional anal ...... in modular polyketide synthase
@nl
prefLabel
Structural and functional anal ...... in modular polyketide synthase
@ast
Structural and functional anal ...... in modular polyketide synthase
@en
Structural and functional anal ...... in modular polyketide synthase
@nl
P2093
P1433
P1476
Structural and functional anal ...... in modular polyketide synthase
@en
P2093
Adrian T Keatinge-Clay
Clint A Taylor
Jianting Zheng
Shawn K Piasecki
P304
P356
10.1016/J.STR.2010.04.015
P577
2010-08-11T00:00:00Z