Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6 - Test2 - elhamkhani - TriplyDB

Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

http://www.wikidata.org/entity/Q27666081

about

A designed redox-controlled caspase Zinc-mediated Allosteric Inhibition of Caspase-6 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.Crystal structure of a Trypanosoma brucei metacaspase Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.Sox11 Reduces Caspase-6 Cleavage and Activity.Small Molecule Active Site Directed Tools for Studying Human Caspases An optimized activity-based probe for the study of caspase-6 activation.New approaches for dissecting protease functions to improve probe development and drug discovery Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3.A tunable, modular approach to fluorescent protease-activated reporters.Comparative structural analysis of the caspase family with other clan CD cysteine peptidases.Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency.Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.Mechanism of zinc-mediated inhibition of caspase-9.Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases.Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.Caspase-6 latent state stability relies on helical propensity.Palmitoylation of caspase-6 by HIP14 regulates its activation.The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.Modifications to a common phosphorylation network provide individualized control in caspases.Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.Modulation of procaspase-7 self-activation by PEST amino acid residues of the N-terminal prodomain and intersubunit linker.Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.Caspase-9 CARD : core domain interactions require a properly formed active site.

P2860

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P2860

Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

http://www.wikidata.org/entity/Q27666081

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

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Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

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Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

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type

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Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

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Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

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Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

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Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

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Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

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Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

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J.JMB.2010.11.031

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Journal of Molecular Biology

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Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

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Elih M Velázquez-Delgado

http://www.w3.org/2001/XMLSchema#string

Genevieve Abbruzzese

http://www.w3.org/2001/XMLSchema#string

Jeanne A Hardy

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Sravanti Vaidya

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P2860

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

Structural basis of caspase-7 inhibition by XIAP

Mechanism of XIAP-mediated inhibition of caspase-9

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction

The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis

The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity

Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding

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