Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
about
Nature-inspired design of motif-specific antibody scaffoldsCombined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demisePhage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafishTunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selectionA multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.Modifying caspase-3 activity by altering allosteric networks.An improved single-chain Fab platform for efficient display and recombinant expression.Turning on caspases with genetics and small moleculesRecombinant renewable polyclonal antibodies.Small Molecule Active Site Directed Tools for Studying Human CaspasesA High Through-put Platform for Recombinant Antibodies to Folded Proteins.Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.A Novel β-adaptin/c-Myc Complex Formation Modulated by Oxidative Stress in the Control of the Cell Cycle in Macrophages and its Implication in Atherogenesis.Engineering a light-activated caspase-3 for precise ablation of neurons in vivo.Human antibody-based chemically induced dimerizers for cell therapeutic applications.Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach.Cleavage of Procaspase-3 by the apoptosomeModulation of procaspase-7 self-activation by PEST amino acid residues of the N-terminal prodomain and intersubunit linker.
P2860
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P2860
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
@ast
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
@en
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
@nl
type
label
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
@ast
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
@en
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
@nl
prefLabel
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
@ast
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
@en
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
@nl
P2093
P2860
P356
P1476
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
@en
P2093
James A Wells
James T Koerber
Nathan D Thomsen
P2860
P304
P356
10.1073/PNAS.1306759110
P407
P577
2013-05-06T00:00:00Z