Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
about
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activationA-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association.A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosisEngineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activationStructural basis for the activation of human procaspase-7Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase AutoactivationMechanism of procaspase-8 activation by c-FLIPLL2′ loop is critical for caspase-7 active site formationSubstrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3.Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxinsA designed redox-controlled caspaseA Class of Allosteric Caspase Inhibitors Identified by High-Throughput ScreeningPorphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine PeptidasesStructural snapshots reveal distinct mechanisms of procaspase-3 and -7 activationAllosteric modulation of caspase 3 through mutagenesisMechanistic insights into CED-4-mediated activation of CED-3Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selectionIdentification of targetable FGFR gene fusions in diverse cancers.Crystal structure of the yeast metacaspase Yca1.Caspase-activated cell-penetrating peptides reveal temporal coupling between endosomal release and apoptosis in an RGC-5 cell model.Discovery of an allosteric site in the caspasesA multi-factor model for caspase degradome predictionLarge-scale preparation of active caspase-3 in E. coli by designing its thrombin-activatable precursorsAllosteric regulation of protease activity by small molecules.Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine.Apoptosis block as a barrier to effective therapy in non small cell lung cancerOligomerization and activation of caspase-9, induced by Apaf-1 CARD.Mechanism and specificity of the human paracaspase MALT1.Activation of caspases-8 and -10 by FLIP(L).Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complexA multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.Human caspases: activation, specificity, and regulationMutations in the procaspase-3 dimer interface affect the activity of the zymogen.Reassembly of active caspase-3 is facilitated by the propeptide.Targeting cell death in tumors by activating caspases.An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3.Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3.Turning on caspases with genetics and small moleculesThe mitochondrial death pathway: a promising therapeutic target in diseases
P2860
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P2860
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Crystal structure of a procasp ...... tivation and substrate binding
@ast
Crystal structure of a procasp ...... tivation and substrate binding
@en
Crystal structure of a procasp ...... tivation and substrate binding
@nl
type
label
Crystal structure of a procasp ...... tivation and substrate binding
@ast
Crystal structure of a procasp ...... tivation and substrate binding
@en
Crystal structure of a procasp ...... tivation and substrate binding
@nl
prefLabel
Crystal structure of a procasp ...... tivation and substrate binding
@ast
Crystal structure of a procasp ...... tivation and substrate binding
@en
Crystal structure of a procasp ...... tivation and substrate binding
@nl
P2093
P1433
P1476
Crystal structure of a procasp ...... tivation and substrate binding
@en
P2093
P304
P356
10.1016/S0092-8674(01)00544-X
P407
P577
2001-11-01T00:00:00Z