The structural basis of agonist-induced activation in constitutively active rhodopsin
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Structure of the human κ-opioid receptor in complex with JDTicCrystal structure of the β2 adrenergic receptor-Gs protein complexCharting a Path to Success in Virtual ScreeningDiversity and modularity of G protein-coupled receptor structuresLarge-scale production and protein engineering of G protein-coupled receptors for structural studiesNew insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptorsConstitutively active rhodopsin and retinal diseaseOverexpression of membrane proteins in mammalian cells for structural studiesCardiac contractility structure-activity relationship and ligand-receptor interactions; the discovery of unique and novel molecular switches in myosuppressin signalingThe role of water in activation mechanism of human N-formyl peptide receptor 1 (FPR1) based on molecular dynamics simulationsCrystal structure of rhodopsin bound to arrestin by femtosecond X-ray laserStructure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and CaffeineStructure of the agonist-bound neurotensin receptorStabilized G protein binding site in the structure of constitutively active metarhodopsin-IICrystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal stateInsights into congenital stationary night blindness based on the structure of G90D rhodopsinStructure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coliA transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.Nanobody stabilization of G protein-coupled receptor conformational states.Activation mechanism of endothelin ETB receptor by endothelin-1Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsLigand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1Lipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulationsEnhancing Protein Expression in HEK-293 Cells by Lowering Culture TemperatureRetinal conformation governs pKa of protonated Schiff base in rhodopsin activationStructure and dynamics of DRD4 bound to an agonist and an antagonist using in silico approaches.Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors.Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes.Differential light-induced responses in sectorial inherited retinal degeneration.The role of experimental and computational structural approaches in 7TM drug discovery.Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors.The experiences of a biochemist in the evolving world of G protein-dependent signaling.Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkMolecular simulations and solid-state NMR investigate dynamical structure in rhodopsin activation.Characterizing and predicting the functional and conformational diversity of seven-transmembrane proteins.Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy.Signaling by sensory receptorsLigand/kappa-opioid receptor interactions: insights from the X-ray crystal structure.Small-molecule antagonists of melanopsin-mediated phototransduction.
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P2860
The structural basis of agonist-induced activation in constitutively active rhodopsin
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The structural basis of agonist-induced activation in constitutively active rhodopsin
@ast
The structural basis of agonist-induced activation in constitutively active rhodopsin
@en
The structural basis of agonist-induced activation in constitutively active rhodopsin
@nl
type
label
The structural basis of agonist-induced activation in constitutively active rhodopsin
@ast
The structural basis of agonist-induced activation in constitutively active rhodopsin
@en
The structural basis of agonist-induced activation in constitutively active rhodopsin
@nl
prefLabel
The structural basis of agonist-induced activation in constitutively active rhodopsin
@ast
The structural basis of agonist-induced activation in constitutively active rhodopsin
@en
The structural basis of agonist-induced activation in constitutively active rhodopsin
@nl
P2093
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P1476
The structural basis of agonist-induced activation in constitutively active rhodopsin
@en
P2093
Aaron D'Antona
Daniel D Oprian
Gebhard F X Schertler
Maikel Fransen
Patricia C Edwards
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P2888
P304
P3181
P356
10.1038/NATURE09795
P407
P577
2011-03-31T00:00:00Z
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P6179
1021434099