Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation
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Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in DiseaseEmerging Molecular and Biological Functions of MBD2, a Reader of DNA MethylationStructural Characterization of a Mouse Ortholog of Human NEIL3 with a Marked Preference for Single-Stranded DNAActivity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pHStructural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residuesRole of base excision repair in maintaining the genetic and epigenetic integrity of CpG sitesMBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological rolesBase excision repairNon-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylomeStructure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidasesA screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation.MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress.Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylationSolution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches.The carboxy-terminal domain of ROS1 is essential for 5-methylcytosine DNA glycosylase activityThe emerging nexus of active DNA demethylation and mitochondrial oxidative metabolism in post-mitotic neuronsComplex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombinationDifferential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNAMechanisms of base substitution mutagenesis in cancer genomes.5-hydroxymethylcytosine: a potential therapeutic target in cancer.Methyl-CpG-binding domain proteins: readers of the epigenome.MBD4 Facilitates Immunoglobulin Class Switch Recombination.A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks.Structural and mutation studies of two DNA demethylation related glycosylases: MBD4 and TDG.Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNAProteins That Read DNA Methylation.Quantification of the sixth DNA base 5-hydroxymethylcytosine in colorectal cancer tissue and C-26 cell line.Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis.Search for Modified DNA Sites with the Human Methyl-CpG-Binding Enzyme MBD4.TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells.TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation.Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni.Base Flipping
P2860
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P2860
Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Excision of thymine and 5-hydr ...... s for active DNA demethylation
@ast
Excision of thymine and 5-hydr ...... s for active DNA demethylation
@en
Excision of thymine and 5-hydr ...... s for active DNA demethylation
@nl
type
label
Excision of thymine and 5-hydr ...... s for active DNA demethylation
@ast
Excision of thymine and 5-hydr ...... s for active DNA demethylation
@en
Excision of thymine and 5-hydr ...... s for active DNA demethylation
@nl
prefLabel
Excision of thymine and 5-hydr ...... s for active DNA demethylation
@ast
Excision of thymine and 5-hydr ...... s for active DNA demethylation
@en
Excision of thymine and 5-hydr ...... s for active DNA demethylation
@nl
P2860
P3181
P356
P1476
Excision of thymine and 5-hydr ...... s for active DNA demethylation
@en
P2093
Xiaodong Cheng
Xing Zhang
P2860
P304
P3181
P356
10.1093/NAR/GKS628
P407
P577
2012-06-27T00:00:00Z