A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma Virulence
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Mice infected with low-virulence strains of Toxoplasma gondii lose their innate aversion to cat urine, even after extensive parasite clearanceStructure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18Structure of the Toxoplasma gondii ROP18 Kinase Domain Reveals a Second Ligand Binding Pocket Required for Acute VirulenceSecreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteinsThe Irish potato famine pathogen Phytophthora infestans translocates the CRN8 kinase into host plant cellsThe Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.Modulation of innate immunity by Toxoplasma gondii virulence effectors.Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistanceThe Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases.Subversion of host cellular functions by the apicomplexan parasites.The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factorsToxoplasma gondii effectors are master regulators of the inflammatory response.Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling.A comparative study of small RNAs in Toxoplasma gondii of distinct genotypes.Structural Basis for the Non-catalytic Functions of Protein Kinases.Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity.The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7.Rhoptry protein 5 (ROP5) Is a Key Virulence Factor in Neospora caninum.A pseudokinase debut at the mycobacterial cell wall.Screening for small molecule inhibitors of Toxoplasma gondii.Dawn of the dead: protein pseudokinases signal new adventures in cell biology.Techniques to examine nucleotide binding by pseudokinases.Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18.Nucleotide-binding mechanisms in pseudokinases.Evaluation of immune responses induced by rhoptry protein 5 and rhoptry protein 7 DNA vaccines against Toxoplasma gondii.Characterization of the Neospora caninum NcROP40 and NcROP2Fam-1 rhoptry proteins during the tachyzoite lytic cycle.The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading.Toxoplasma gondii sexual cross in a single naturally infected feline host: generation of highly mouse-virulent and avirulent clones, genotypically different from clonal types I, II and III.Functional analysis of Toxoplasma lactate dehydrogenases suggests critical roles of lactate fermentation for parasite growth in vivo.Characterization of Ligand Binding to Pseudokinases Using a Thermal Shift Assay.TgTKL1 Is a Unique Plant-Like Nuclear Kinase That Plays an Essential Role in Acute Toxoplasmosis.
P2860
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P2860
A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma Virulence
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A Conserved Non-canonical Moti ...... Effect on Toxoplasma Virulence
@ast
A Conserved Non-canonical Moti ...... Effect on Toxoplasma Virulence
@en
A Conserved Non-canonical Moti ...... Effect on Toxoplasma Virulence
@nl
type
label
A Conserved Non-canonical Moti ...... Effect on Toxoplasma Virulence
@ast
A Conserved Non-canonical Moti ...... Effect on Toxoplasma Virulence
@en
A Conserved Non-canonical Moti ...... Effect on Toxoplasma Virulence
@nl
prefLabel
A Conserved Non-canonical Moti ...... Effect on Toxoplasma Virulence
@ast
A Conserved Non-canonical Moti ...... Effect on Toxoplasma Virulence
@en
A Conserved Non-canonical Moti ...... Effect on Toxoplasma Virulence
@nl
P2860
P3181
P356
P1476
A Conserved Non-canonical Moti ...... Effect on Toxoplasma Virulence
@en
P2093
John C Boothroyd
Michael L Reese
P2860
P304
P3181
P356
10.1074/JBC.M111.253435
P407
P577
2011-08-19T00:00:00Z