A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response - Test2 - elhamkhani - TriplyDB

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

http://www.wikidata.org/entity/Q27670940

about

Studying epigenetic complexes and their inhibitors with the proteomics toolbox Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation Epigenetic regulators and their impact on therapy in acute myeloid leukemia Epigenetic Modulators of Monocytic Function: Implication for Steady State and Disease in the CNS Open access chemical probes for epigenetic targets The complexity of epigenetic diseases Epigenetic regulation by histone demethylases in hypoxia Design of small molecule epigenetic modulators High-throughput screening to identify inhibitors of lysine demethylases Epigenetics: the fine-tuner in inflammatory bowel disease?Anti-inflammatory therapy in chronic disease: challenges and opportunities Mechanisms of epigenetic regulation of leukemia onset and progression Carbon-oxygen hydrogen bonding in biological structure and function Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention Chromatin targeting drugs in cancer and immunity Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer Developing epigenetic diagnostics and therapeutics for brain disorders Chromatin signatures of cancer 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors Human UTY(KDM6C) Is a Male-specific N -Methyl Lysyl Demethylase Ribosomal oxygenases are structurally conserved from prokaryotes to humans Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells Structural analysis of human KDM5B guides histone demethylase inhibitor development Use of ferrous iron by metallo-β-lactamases Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications Contribution of metabolic reprogramming to macrophage plasticity and function Epigenome-modifying tools in asthma JMJD3 as an epigenetic regulator in development and disease The mechanisms behind the therapeutic activity of BET bromodomain inhibition Open access target validation is a more efficient way to accelerate drug discovery The M1 and M2 paradigm of macrophage activation: time for reassessment Role of Serum Amyloid A, Granulocyte-Macrophage Colony-Stimulating Factor, and Bone Marrow Granulocyte-Monocyte Precursor Expansion in Segmented Filamentous Bacterium-Mediated Protection from Entamoeba histolytica.Inhibition of H3K27me3 Histone Demethylase Activity Prevents the Proliferative Regeneration of Zebrafish Lateral Line Neuromasts.Assessing histone demethylase inhibitors in cells: lessons learned.Open Access Could Transform Drug Discovery: A Case Study of JQ1.Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation.Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification.

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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

http://www.wikidata.org/entity/Q27670940

description

2012 nî lūn-bûn

@nan

2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

A selective jumonji H3K27 deme ...... flammatory macrophage response

@ast

A selective jumonji H3K27 deme ...... flammatory macrophage response

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A selective jumonji H3K27 deme ...... flammatory macrophage response

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type

label

A selective jumonji H3K27 deme ...... flammatory macrophage response

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A selective jumonji H3K27 deme ...... flammatory macrophage response

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A selective jumonji H3K27 deme ...... flammatory macrophage response

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prefLabel

A selective jumonji H3K27 deme ...... flammatory macrophage response

@ast

A selective jumonji H3K27 deme ...... flammatory macrophage response

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A selective jumonji H3K27 deme ...... flammatory macrophage response

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A selective jumonji H3K27 deme ...... flammatory macrophage response

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Angela Bridges

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Anthony Tumber

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Catherine Swales

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Gerard Joberty

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P2860

Thousands of chemical starting points for antimalarial lead identification

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans

Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A

Chromatin modifications and their function

The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

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scholarly article

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59708

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10.1038/NATURE11262

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7411

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488

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Christopher J. Schofield

Dinshaw J. Patel

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2012-08-16T00:00:00Z

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1049884134

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22842901

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4691848

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