Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons
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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesInterferon lambda: a new sword in cancer immunotherapyDifferential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infectionsInsights into cytokine-receptor interactions from cytokine engineeringInterferon gamma receptor: the beginning of the journeySubversion of cytokine networks by virally encoded decoy receptorsReceptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signalingA Single N-Acetylgalactosamine Residue at Threonine 106 Modifies the Dynamics and Structure of Interferon 2a around the Glycosylation SiteStructural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosusStructure of the activating IL-1 receptor signaling complexStructural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potencyDisease-promoting effects of type I interferons in viral, bacterial, and coinfectionsInterferons and viruses: an evolutionary arms race of molecular interactionsStructural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1Interferon-ε protects the female reproductive tract from viral and bacterial infectionContraction of the type I IFN locus and unusual constitutive expression of IFN-α in batsFunctional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO MutationMembrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes.Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes.Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membraneReceptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.How type I interferons work in multiple sclerosis and other diseases: some unexpected mechanisms.Interferons and their stimulated genes in the tumor microenvironmentType I interferon mimetics bypass vaccinia virus decoy receptor virulence factor for protection of mice against lethal infection.Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions.High-density nucleosome occupancy map of human chromosome 9p21-22 reveals chromatin organization of the type I interferon gene cluster.Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity.Short peptide type I interferon mimetics: therapeutics for experimental allergic encephalomyelitis, melanoma, and viral infectionsMolecular evolution of the porcine type I interferon family: subtype-specific expression and antiviral activity.Differential activity of type I interferon subtypes for dendritic cell differentiationType I interferons link viral infection to enhanced epithelial turnover and repair.Multifaceted activities of type I interferon are revealed by a receptor antagonist.Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibodyBlockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infectionEvolutionary genetic dissection of human interferons.Inborn errors of anti-viral interferon immunity in humans.The molecular basis of IL-10 function: from receptor structure to the onset of signaling.Experimental Neuromyelitis Optica Induces a Type I Interferon Signature in the Spinal Cord.A fully human monoclonal antibody with novel binding epitope and excellent neutralizing activity to multiple human IFN-α subtypes: A candidate therapy for systemic lupus erythematosus.
P2860
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P2860
Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Structural Linkage between Lig ...... tivation by Type I Interferons
@ast
Structural Linkage between Lig ...... tivation by Type I Interferons
@en
Structural Linkage between Lig ...... tivation by Type I Interferons
@nl
type
label
Structural Linkage between Lig ...... tivation by Type I Interferons
@ast
Structural Linkage between Lig ...... tivation by Type I Interferons
@en
Structural Linkage between Lig ...... tivation by Type I Interferons
@nl
prefLabel
Structural Linkage between Lig ...... tivation by Type I Interferons
@ast
Structural Linkage between Lig ...... tivation by Type I Interferons
@en
Structural Linkage between Lig ...... tivation by Type I Interferons
@nl
P2093
P2860
P3181
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Structural linkage between lig ...... tivation by type I interferons
@en
P2093
Angelica Trejo
Choongho Lee
Doron Levin
Ganit Yarden
Garry P Nolan
Gideon Schreiber
Ignacio Moraga
Jacob Piehler
Jeffrey S Glenn
K Christopher Garcia
P2860
P304
P3181
P356
10.1016/J.CELL.2011.06.048
P407
P577
2011-08-01T00:00:00Z