Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation. - Test2 - elhamkhani - TriplyDB

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.

http://www.wikidata.org/entity/Q27687338

about

Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types Insights into cytokine-receptor interactions from cytokine engineering Dendritic cells in human Pneumovirus and Metapneumovirus infections Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency Disease-promoting effects of type I interferons in viral, bacterial, and coinfections Interferons and viruses: an evolutionary arms race of molecular interactions A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses High efficiency cell-specific targeting of cytokine activity Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes.Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons Plasmacytoid dendritic cell-derived IFN-α promotes murine liver ischemia/reperfusion injury by induction of hepatocyte IRF-1.Interferons and their stimulated genes in the tumor microenvironment Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of type I IFN production.Multifaceted activities of type I interferon are revealed by a receptor antagonist.Quantitative analysis of receptor tyrosine kinase-effector coupling at functionally relevant stimulus levels.Type I interferon controls propagation of long interspersed element-1.A Residue Quartet in the Extracellular Domain of the Prolactin Receptor Selectively Controls Mitogen-activated Protein Kinase Signaling Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection Interferon Beta and Interferon Alpha 2a Differentially Protect Head and Neck Cancer Cells from Vesicular Stomatitis Virus-Induced Oncolysis.Binding of interferon reduces the force of unfolding for interferon receptor 1.Type I interferons mediate pancreatic toxicities of PERK inhibition.Physiological evidence for diversification of IFNα- and IFNβ-mediated response programs in different autoimmune diseases Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression STAT2 phosphorylation and signaling.Bridging the species divide: transgenic mice humanized for type-I interferon response.Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex.Critical roles for Rictor/Sin1 complexes in interferon-dependent gene transcription and generation of antiproliferative responses.Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury.Multifarious determinants of cytokine receptor signaling specificity.Cytokine immunomodulation for the treatment of infectious diseases: lessons from primary immunodeficiencies.Cumulus cell-expressed type I interferons induce cumulus expansion in mice.IFNA2: The prototypic human alpha interferon.Peginterferon α-2a for the treatment of HIV infection.Insights into immune structure, recognition, and signaling.Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes.Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation.Type I interferons promote severe disease in a mouse model of lethal ehrlichiosis.Fine Tuning of a Type 1 Interferon Antagonist.

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Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.

http://www.wikidata.org/entity/Q27687338

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2012 nî lūn-bûn

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Christoph Thomas

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Gideon Schreiber

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Jacob Piehler

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K.Christopher Garcia

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P2860

SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor

Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA

The human interferon alpha/beta receptor: characterization and molecular cloning

Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor

UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

A diverse range of gene products are effectors of the type I interferon antiviral response

Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif

INTERFEROME: the database of interferon regulated genes

Structure of IL-22 bound to its high-affinity IL-22R1 chain

Ubiquitination-mediated regulation of interferon responses

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