Optimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

Optimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

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http://www.wikidata.org/entity/Q27674324
Aurora Kinase Inhibitors: Current Status and OutlookAurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.Targeted drug discovery for pediatric leukemia.Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluationA phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia.7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituentFacile identification of dual FLT3-Aurora A inhibitors: a computer-guided drug design approach.Discovery of 7-aryl-substituted (1,5-naphthyridin-4-yl)ureas as aurora kinase inhibitors.High-dimensional QSAR modelling using penalized linear regression model with L1/2-norm.A Simple Precursor for Highly Functionalized Fused Imidazo[4,5-b]pyridines and Imidazo[4,5-b]-1,8-naphthyridine.Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.Copper(I)-Catalyzed Regioselective C-H Amination of N -Pyridyl Imines Using Azidotrimethylsilane and TBHP: A One-Pot, Domino Approach to Substituted Imidazo[4, 5-b]pyridines
P2860

Optimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

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http://www.wikidata.org/entity/Q27674324
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2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
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P2093
P2860
P304
P31
P356
P407
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P50
P577
P5875
P698
P921
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Optimization of Imidazo[4,5- b ...... ment of Acute Myeloid Leukemia
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932