about
Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domainStructural basis of Aurora-A activation by TPX2 at the mitotic spindleGLFG and FxFG nucleoporins bind to overlapping sites on importin-betaA cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle bindingMolecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugsAurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle AssemblyInteraction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDPStructural basis for the interaction between NTF2 and nucleoporin FxFG repeats.NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion systemIdentification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPaseInsights into the Conformational Variability and Regulation of Human Nek2 KinaseA Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome CondensationAn Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug designImidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidateStructure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cellsStructural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural CharacterizationBenzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationshipOptimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid LeukemiaDesign of Potent and Selective Hybrid Inhibitors of the Mitotic Kinase Nek2: Structure–Activity Relationship, Structural Biology, and Cellular ActivityInsights into Aurora-A Kinase Activation Using Unnatural Amino Acids Incorporated by Chemical ModificationAurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiationMicrotubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domainEfficient genetic encoding of phosphoserine and its nonhydrolyzable analogDiverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modificationA new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinaseTACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylationNeurodevelopmental protein Musashi 1 interacts with the Zika genome and promotes viral replication.Agrobacterium VirB10 domain requirements for type IV secretion and T pilus biogenesis.The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pyloriMolecular mechanism of translocation through nuclear pore complexes during nuclear protein import.Dimerization and interactions of Brucella suis VirB8 with VirB4 and VirB10 are required for its biological activity.Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergisticStructural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains.
P50
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P50
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hulumtues
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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Richard Bayliss
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P106
P1153
7006769658
P2031
1999-01-01T00:00:00Z
P21
P31
P496
0000-0003-0604-2773