Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes - Test2 - elhamkhani - TriplyDB

Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes

Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes

http://www.wikidata.org/entity/Q27675332

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Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8 The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair Building and remodelling Cullin-RING E3 ubiquitin ligases Nα-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain Ubiquitylation, neddylation and the DNA damage response The biological functions of Naa10 - From amino-terminal acetylation to human disease Structural and functional insights to ubiquitin-like protein conjugation.Protein neddylation: beyond cullin-RING ligases.Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1)Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway Squamous Cell Carcinoma-related Oncogene (SCCRO) Family Members Regulate Cell Growth and Proliferation through Their Cooperative and Antagonistic Effects on Cullin Neddylation.Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway NEDDylation promotes stress granule assembly.DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage.The N-terminal methionine of cellular proteins as a degradation signal Signal transduction: From the atomic age to the post-genomic era Formyl-methionine as a degradation signal at the N-termini of bacterial proteins.Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway.Neddylation A Functional Link Between NAD+ Homeostasis and N-terminal Protein Acetylation in Saccharomyces cerevisiae.Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21 protein complex during abscission.Molecular determinants of the N-terminal acetyltransferase Naa60 anchoring to the Golgi membrane.NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression.Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae.The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.

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Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes

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Structural Conservation of Dis ...... mmalian NEDD8 Ligation Enzymes

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Brenda A Schulman

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Daniel C Scott

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Darcie J Miller

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David King

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Eric J Bennett

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J Wade Harper

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John Lydeard

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Julie K Monda

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P2860

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

Structure and ligand of a histone acetyltransferase bromodomain

Selective inhibition of BET bromodomains

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification

SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p

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