Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90
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Hsp90: A New Player in DNA Repair?Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90Drosophila as an In Vivo Model for Human Neurodegenerative Disease19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity.BRCA-Monet: a breast cancer specific drug treatment mode-of-action network for treatment effective prediction using large scale microarray database.Natalamycin A, an Ansamycin from a Termite-Associated Streptomyces sp.HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.Conformation-activity relationships of polyketide natural products.Production of 17-O-demethyl-geldanamycin, a cytotoxic ansamycin polyketide, by Streptomyces hygroscopicus DEM20745.A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.Heat shock protein 90 controls HIV-1 reactivation from latency.Association of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door?Mccrearamycins A-D, Geldanamycin-Derived Cyclopentenone Macrolactams from an Eastern Kentucky Abandoned Coal Mine Microbe.Synthesis and biological evaluation of geldanamycin analogs against human cancer cells.New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90.Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors.A structurally simplified analogue of geldanamycin exhibits neuroprotective activity.An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration.Biasing Potential Replica Exchange Multisite λ-Dynamics for Efficient Free Energy Calculations.Computational predictions of corroles as a class of Hsp90 inhibitors.Towards natural mimetics of metformin and rapamycin.Total synthesis of (-)-deguelin via an iterative pyran-ring formation strategy.Construction and in vitro/in vivo evaluation of 17-allylamino-17-demethoxygeldanamycin (17AAG)-loaded PEGylated nanostructured lipid carriers.
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P2860
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90
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2013 nî lūn-bûn
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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Synthesis of 19-substituted ge ...... ng to heat shock protein Hsp90
@ast
Synthesis of 19-substituted ge ...... ng to heat shock protein Hsp90
@en
Synthesis of 19-substituted ge ...... ng to heat shock protein Hsp90
@nl
type
label
Synthesis of 19-substituted ge ...... ng to heat shock protein Hsp90
@ast
Synthesis of 19-substituted ge ...... ng to heat shock protein Hsp90
@en
Synthesis of 19-substituted ge ...... ng to heat shock protein Hsp90
@nl
prefLabel
Synthesis of 19-substituted ge ...... ng to heat shock protein Hsp90
@ast
Synthesis of 19-substituted ge ...... ng to heat shock protein Hsp90
@en
Synthesis of 19-substituted ge ...... ng to heat shock protein Hsp90
@nl
P2093
P2860
P50
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Synthesis of 19-substituted ge ...... ng to heat shock protein Hsp90
@en
P2093
Adrienne L Davis
Chuan-Hsin Chang
David Ross
David Siegel
Donna L Dehn
Huw E L Williams
Russell R A Kitson
S Mark Roe
P2860
P2888
P304
P356
10.1038/NCHEM.1596
P577
2013-04-01T00:00:00Z
P5875
P6179
1029895479