Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
about
Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein - The role of hsp90Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradationA proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting proteinHSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathwayDistinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicolThe Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKRCoupling between catalytic site and collective dynamics: a requirement for mechanochemical activity of enzymesThe ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domainsCytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulumThe heat shock protein 90 of Plasmodium falciparum and antimalarial activity of its inhibitor, geldanamycinInhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicolParalog Specific Hsp90 Inhibitors - A Brief History and a Bright FutureReview: The HSP90 molecular chaperone-an enigmatic ATPaseMolecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugsHsp90: A New Player in DNA Repair?Maximizing the Therapeutic Potential of HSP90 InhibitorsTargeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseasesProposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's DiseaseTargeting Hsp90 in urothelial carcinomaHsp90 selectively modulates phenotype in vertebrate developmentDihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease.Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimerMonovalent cation dependence and preference of GHKL ATPases and kinasesDifferent Poses for Ligand and Chaperone in Inhibitor-Bound Hsp90 and GRP94: Implications for Paralog-Specific Drug DesignStructure of the ATP-binding domain of Plasmodium falciparum Hsp90Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitorsApplication of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDockThe C-terminal domain of human Cdc37 studied by solution NMRThe heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperoneElucidation of the Hsp90 C-terminal inhibitor binding siteDrugging the cancer kinome: progress and challenges in developing personalized molecular cancer therapeuticsAssociation between Hsp90 and the ClC-2 chloride channel upregulates channel functionDrugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stressGeldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperonesAn essential role of Glu-243 and His-239 in the phosphotransfer reaction catalyzed by pyruvate dehydrogenase kinaseGenome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicansHsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurinRapid and accurate prediction and scoring of water molecules in protein binding sites
P2860
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P2860
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Structural basis for inhibitio ...... ics radicicol and geldanamycin
@ast
Structural basis for inhibitio ...... ics radicicol and geldanamycin
@en
Structural basis for inhibitio ...... ics radicicol and geldanamycin
@nl
type
label
Structural basis for inhibitio ...... ics radicicol and geldanamycin
@ast
Structural basis for inhibitio ...... ics radicicol and geldanamycin
@en
Structural basis for inhibitio ...... ics radicicol and geldanamycin
@nl
prefLabel
Structural basis for inhibitio ...... ics radicicol and geldanamycin
@ast
Structural basis for inhibitio ...... ics radicicol and geldanamycin
@en
Structural basis for inhibitio ...... ics radicicol and geldanamycin
@nl
P2093
P3181
P356
P1476
Structural basis for inhibitio ...... ics radicicol and geldanamycin
@en
P2093
P3181
P356
10.1021/JM980403Y
P407
P577
1999-01-28T00:00:00Z