Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
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Wnt/beta-catenin signaling and small molecule inhibitorsThe 1.8 A Cholix Toxin Crystal Structure in Complex with NAD+ and Evidence for a New Kinetic ModelEvaluation and Structural Basis for the Inhibition of Tankyrases by PARP InhibitorsEvidence for tankyrases as antineoplastic targets in lung cancer.Identification of poly(ADP-ribose) polymerase-1 as a cell cycle regulator through modulating Sp1 mediated transcription in human hepatoma cells.Scaffold hopping approach on the route to selective tankyrase inhibitors.Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.Structural Implications for Selective Targeting of PARPs.PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.PARP inhibitors in cancer therapy: an update.Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.PARP inhibitors: polypharmacology versus selective inhibition.Tankyrases as drug targets.Tankyrases: structure, function and therapeutic implications in cancer.Recent advances in the structure-based rational design of TNKSIs.A comprehensive look of poly(ADP-ribose) polymerase inhibition strategies and future directions for cancer therapy.Molecular regulation and pharmacological targeting of the β-catenin destruction complex.Exclusive destruction of mitotic spindles in human cancer cells.Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.SEC-TID: A Label-Free Method for Small-Molecule Target Identification.Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.The binding mechanism of a novel nicotinamide isostere inhibiting with TNKSs: a molecular dynamic simulation and binding free energy calculation.
P2860
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P2860
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
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2012年の論文
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2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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name
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
@ast
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
@en
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
@nl
type
label
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
@ast
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
@en
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
@nl
prefLabel
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
@ast
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
@en
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
@nl
P2093
P2860
P921
P1476
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
@en
P2093
Aleem Fazal
Atwood Cheung
Christina A Kirby
Michael D Shultz
Travis Stams
P2860
P356
10.1107/S1744309111051219
P577
2012-02-01T00:00:00Z