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Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human CellsDevelopment of anticancer agents targeting the Wnt/β-catenin signalingChemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative MedicineDesign, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3- b ]pyridazin-8-amine Derivatives as Tankyrase InhibitorsStructure-Based Design of 2-Aminopyridine Oxazolidinones as Potent and Selective Tankyrase InhibitorsEvaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitorspara-Substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitorsTargeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer TherapyTankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin PunctaPoly(ADP-ribosylation) is present in murine sciatic nerve fibers and is altered in a Charcot-Marie-Tooth-1E neurodegenerative model.A role of intracellular mono-ADP-ribosylation in cancer biology.Denervation suppresses gastric tumorigenesis.Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cellsDiscovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.Can we safely target the WNT pathway?Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity.Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin DegradationThe evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapiesE7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling.RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer.PARP inhibitors: polypharmacology versus selective inhibition.Recent advances in the structure-based rational design of TNKSIs.Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms.mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer.Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling.Human Cytomegalovirus Inhibits the PARsylation Activity of Tankyrase--A Potential Strategy for Suppression of the Wnt Pathway.Beyond Telomerase: Telomere Instability as a Novel Target for Cancer Therapy.Inhibition of poly(adenosine diphosphate-ribose) polymerase using quinazolinone nucleus.WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.VERO cells harbor a poly-ADP-ribose belt partnering their epithelial adhesion belt.LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.Developing drugs that target the Wnt pathway: recent approaches in cancer and neurodegenerative diseases.Targeting Tankyrase to Fight WNT-dependent Tumours.Tankyrase inhibitors: potential treatment of hyperproliferative diseases.Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade.Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life.Structural insights into SAM domain-mediated tankyrase oligomerization.Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Tankyrases as drug targets.
@en
type
label
Tankyrases as drug targets.
@en
prefLabel
Tankyrases as drug targets.
@en
P2860
P356
P1433
P1476
Tankyrases as drug targets.
@en
P2093
Nai-Wen Chi
Stefan Krauss
P2860
P304
P356
10.1111/FEBS.12320
P407
P50
P577
2013-06-18T00:00:00Z