Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain
about
RTX proteins: a highly diverse family secreted by a common mechanismThe acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphateHost S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxinsCross Kingdom Activators of Five Classes of Bacterial EffectorsClostridial toxins: sensing a target in a hostile gut environment.Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing in Clostridium difficile Toxin AStructural and Molecular Mechanism for Autoprocessing of MARTX Toxin of Vibrio cholerae at Multiple SitesMechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxinRational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdBDefining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxinsStructure of the catalytic domain of theSalmonellavirulence factor SseIMechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulationCrystal structure of a Trypanosoma brucei metacaspaseStructure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase familyFunctional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitorsSimplified, enhanced protein purification using an inducible, autoprocessing enzyme tagThe Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies.Using small molecules to dissect mechanisms of microbial pathogenesis.Small-molecule activators of a proenzyme.Allosteric regulation of protease activity by small molecules.Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins.BINANA: a novel algorithm for ligand-binding characterizationExpression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects.Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.Emerging principles in protease-based drug discovery.Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomicsHuman caspases: activation, specificity, and regulationSmall-molecule procaspase activators identified using fluorescence polarization.Autoproteolytic activation of bacterial toxins.Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxinsCrystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome.Toward a structural understanding of Clostridium difficile toxins A and B.Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.New approaches for dissecting protease functions to improve probe development and drug discoveryRhomboid protease dynamics and lipid interactionsThe origin of allosteric functional modulation: multiple pre-existing pathways.Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms.Regulation of Vibrio parahaemolyticus T3SS2 gene expression and function of T3SS2 effectors that modulate actin cytoskeleton.Comparative structural analysis of the caspase family with other clan CD cysteine peptidases.Two serine residues in Pseudomonas syringae effector HopZ1a are required for acetyltransferase activity and association with the host co-factor.
P2860
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P2860
Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain
@ast
Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain
@en
Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain
@nl
type
label
Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain
@ast
Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain
@en
Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain
@nl
prefLabel
Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain
@ast
Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain
@en
Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain
@nl
P2093
P2860
P356
P1433
P1476
Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain
@en
P2093
Aimee Shen
K Christopher Garcia
Patrick J Lupardus
P2860
P356
10.1126/SCIENCE.1162403
P407
P577
2008-10-10T00:00:00Z